3D Liver Volumetry

NCT07297615 | Not Yet Recruiting

• 1 other identifier: 1465/2025
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to improve preoperative evaluation of liver resection volume in patients undergoing major hepatectomies. Accurate prediction of the planned resection and the future liver remnant (FLR) is critical to minimize the risk of postoperative liver failure, which is associated with increased morbidity and mortality. Conventional imaging-based volumetry may have limited accuracy. This study investigates the use of individualized 3D liver models combined to enhance visualization and volumetric analysis of liver anatomy and resection boundaries. Patients are recruited in the liver outpatient clinic and, upon consent, preoperative 3D models are created using Medics 3D. During surgery, the planned resection is guided by the individualized 3D models. Postoperatively, the resected specimen undergoes CT-based volumetry to compare the predicted resection volume from the 3D model with the actual volume. Routine postoperative follow-up is conducted. The study aims to optimize surgical planning, enhance the accuracy of future liver remnant prediction.

Conditions

Liver Surgery; Liver Cancer; Surgical Planning; Liver; Volumetric Analysis; 3D-reconstruction

Outcome Measures

Primary Outcomes (1)

• Assessment of the preoperative volumetry of the liver portion planned for resection using a 3D model and comparison with the postoperative resection specimen volume.

  Approximately 2-3 weeks are required between preoperative volumetry and postoperative volumetry comparison.

Study Arms (1)

Volumetry through 3D reconstruction

EXPERIMENTAL

Preoperative liver volumetry using individualized 3D reconstructions to guide major hepatectomy, optimize resection planning, and improve prediction of the future liver remnant.

Diagnostic Test: 3d reconstruction

Interventions

3d reconstruction DIAGNOSTIC_TEST

Preoperatively, every patient in this study will undergo an individualized 3D reconstruction of their liver to perform accurate volumetry.

Volumetry through 3D reconstruction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients (≥18 years) undergoing open or minimally invasive major liver resection at the Clinical Division of General, Visceral and Transplant Surgery who provide written informed consent prior to participation will be included.

You may not qualify if:

• Patients unable to provide informed consent will be excluded.
• Minor resections.
• Contraindications to MRI.

Sponsors & Collaborators

• Medical University of Graz: lead

Study Sites (1)

Medical University of Graz - Department of Surgery, Division of General, Visceral and Transplantationsurgery

Graz, Austria

Location

MeSH Terms

Conditions

Liver Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Liver Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: December 22, 2025
• Study Start: April 1, 2026
• Primary Completion (Estimated): March 31, 2028
• Study Completion (Estimated): September 30, 2028
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)