NCT07297303

Brief Summary

Prospective observational study on the clinical characteristics of pulmonary graft-versus-host disease in patients after hematopoietic stem cell transplantation.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for all trials

Timeline
57mo left

Started Sep 2025

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress12%
Sep 2025Dec 2030

Study Start

First participant enrolled

September 30, 2025

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

December 9, 2025

Completed
13 days until next milestone

First Posted

Study publicly available on registry

December 22, 2025

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2030

Last Updated

December 22, 2025

Status Verified

December 1, 2025

Enrollment Period

5.3 years

First QC Date

December 9, 2025

Last Update Submit

December 9, 2025

Conditions

Bronchiolitis Obliterable Syndrome

Keywords

hematopoietic stem cell transplantationGvHDObstructive airway diseasePulmonary rehabilitationCardiopulmonary exercise test

Outcome Measures

Primary Outcomes (1)

  • Prevalence of bronchiolitis obliterans syndrome

    From enrollment to the end of treatment at 2 years

Study Arms (1)

A hematopoietic stem cell transplantation cohort

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

At National Taiwan University Hospital and National Taiwan University Hospital Cancer Center

You may qualify if:

  • Age\>18
  • Will Receive first time Allo-HSCT patients

You may not qualify if:

  • Respiratory failure
  • Hemodynamic unstable
  • Pneumothorax or bronchial fistula
  • Acute coronary syndrome in recent 1 month
  • The patient couldn't walk longer than 20 m
  • Severe lower-limb arthropathy
  • The patient couldn't cooperate well
  • Need all-day oxygen supplement
  • The patient received lung transplantation before

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Lung Diseases, Obstructive

Condition Hierarchy (Ancestors)

Lung DiseasesRespiratory Tract Diseases

Central Study Contacts

Ting-Yu Liao

CONTACT

+886 2312-3456tingyufish0129@gmail.com

Zong-Han Yao

CONTACT

+886 2312-3456med92leoyau@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 9, 2025

First Posted

December 22, 2025

Study Start

September 30, 2025

Primary Completion (Estimated)

December 31, 2030

Study Completion (Estimated)

December 31, 2030

Last Updated

December 22, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

IPD will not be shared due to privacy concerns and limitations specified by the ethics committee/institutional review board.

Locations

TW(1)