Efficacy of Er:YAG Laser in Removing Impacted Mandibular Third Molars

NCT07297043 | Completed

• 1 other identifier: ALEXDEN-KA-IMP_M3-2025
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled clinical trial aims to evaluate the efficacy of the Er:YAG laser in the removal of impacted mandibular third molars compared to the conventional surgical technique. The study assesses surgical efficiency, postoperative pain, swelling, trismus, and overall patient recovery. The goal is to determine whether the Er:YAG laser provides a safer and less traumatic alternative to traditional bone-cutting methods during third molar surgery.

Conditions

Impacted Mandibular Third Molar

Keywords

Third Molar Surgery; Er:YAG Laser; Laser-Assisted Surgery; Oral Surgery

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain Score

  Postoperative pain will be assessed using a Visual Analog Scale (VAS) ranging from 0 (no pain) to 10 (worst pain) at postoperative intervals.

  Immediate postoperative, 24 hours, 3 days, and 7 days

Secondary Outcomes (3)

• Postoperative Swelling

  Immediate postoperative, 24 hours, 3 days, and 7 days

• Postoperative Trismus

  Immediate postoperative, 24 hours, 3 days, and 7 days

• Bone Density

  Immediate postoperative, 1 month, and 3 months

Study Arms (2)

Er:YAG Laser Group

EXPERIMENTAL

Participants in this group will undergo impacted mandibular third molar surgery using the Er:YAG laser for bone removal.

Device: Er:YAG laser

Conventional Rotary Instrument Group

ACTIVE COMPARATOR

Participants in this group will undergo impacted mandibular third molar surgery using conventional rotary instruments (bur and handpiece) for bone cutting.

Procedure: Conventional Rotary Instruments Surgery

Interventions

Er:YAG laser DEVICE

Er:YAG laser (2940 nm) used for bone cutting during impacted mandibular third molar surgery.

Er:YAG Laser Group

Conventional Rotary Instruments Surgery PROCEDURE

Conventional rotary instruments used for bone removal during surgical extraction of impacted mandibular third molars.

Conventional Rotary Instrument Group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 20-30 years requiring surgical extraction of a mesioangular impacted mandibular third molar.
• Healthy individuals with no systemic diseases that may influence bone metabolism or wound healing.
• Good oral hygiene and absence of local infection at the surgical site.
• No contraindications to local anesthesia, surgical extraction, or use of the Er:YAG laser.
• Radiographic evidence confirming normal bone structure without cysts or pathological lesions.
• Willingness to participate and ability to provide informed consent.

You may not qualify if:

• Systemic medical conditions affecting bone healing or postoperative response (e.g., uncontrolled diabetes, immunodeficiency, metabolic bone disorders).
• Current or recent use of medications influencing bone remodeling (e.g., bisphosphonates, corticosteroids, immunosuppressants).
• Heavy smoking (\>10 cigarettes/day).
• Pregnant or breastfeeding females.
• Poor oral hygiene, active infection, or pericoronitis at the surgical site.
• Previous surgery, trauma, or pathology in the mandibular third molar region.
• Known allergies or contraindications to any material or procedure used in the study.

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Faculty of Dentistry, Alexandria University

Alexandria, Alexandria Governorate, Egypt

Location

MeSH Terms

Interventions

Lasers, Solid-State

Intervention Hierarchy (Ancestors)

Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Study Officials

• Karim Elhaw, MSc (Oral Laser Applications)

  Alexandria University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: No masking was performed because both the surgeon and the participants were aware of the intervention type.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postgraduate Researcher, Oral Laser Applications

Model Details: Participants are randomly assigned into two parallel groups: Er:YAG laser-assisted surgery and conventional rotary instrument surgery.

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: December 22, 2025
• Study Start: September 25, 2024
• Primary Completion: January 15, 2025
• Study Completion: January 29, 2025
• Last Updated: December 29, 2025

Record last verified: 2025-12

Locations

EG (1)