Naples Prognostic Score for Predicting Postoperative Delirium

NCT07297017 | Recruiting

• 1 other identifier: ِAIP003-7
• Study Type: observational
• Target: 168
• Locations: 1 country
• Sites: 1

Brief Summary

Naples Prognostic Score (NPS) originally developed to predict outcomes in inflammatory and malignant conditions; we asked if it can effectively predict postoperative delirium (POD) in elderly patients undergoing hip surgery? NPS integrate markers such as albumin, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio-all of which have been linked to adverse postoperative outcomes including POD.

Conditions

Postoperative Delirium

Keywords

POD; elderly; geriatric; NPS

Outcome Measures

Primary Outcomes (1)

• Assessment of postoperative delirium

  Assessment of postoperative deliurim will be done once daily by using an established screening instrument (The Confusion Assessment Method (CAM)). A positive CAM requires both (1) Acute onset \& fluctuating course AND (2) Inattention, plus (3) Disorganized thinking OR (4) Altered level of consciousness.

  on arrival to PACU, on postoperative day 1, 2, 3, 5, 7.

Secondary Outcomes (1)

• Length of hospital stay

  Directly before patients' discharge from hospital

Study Arms (1)

hip group

patients undergoing hip surgeries will be screened for delirium in the Post-Anesthesia Care Unit (PACU) on arrival, and once daily for the first 3 postoperative days (postoperative days 1 to 3), and on postoperative days 5 and 7.

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

elderly patients undergoing Hip fracture surgery

You may qualify if:

• The elderly age≥60 years
• American Society of Anesthesiologists (ASA) classification II∼IV
• Patients undergoing hip fracture surgery
• Patients who had a complete blood sample were taken preoperatively

You may not qualify if:

• Patient refused to participate and consent
• Patients with a history of mild cognitive impairment (MCI), dementia, and delirium
• Ptients with known preoperative infections (pulmonary infection, urinary infection, and sepsis).

Sponsors & Collaborators

• South Valley University: lead

Study Sites (1)

Qena University

Qina, Qena Governorate, 83511, Egypt

RECRUITING

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Zeinab M Sayed, MD

CONTACT

+201009071365; zeinab5aton@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer in anesthesia, Intensive Care and Pain Management

Study Record Dates

• First Submitted: November 25, 2025
• First Posted: December 22, 2025
• Study Start: January 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: January 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)