NCT07295795

Completed

Blood Sampling Pre- and Post-Propofol Administration to Char...

National Institutes of Health Clinical Center (CC)Source

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Other study identifiers

Sponsor study identifier

10002371

Secondary identifiers

002371-CC

Study Type

observational

Actual enrollment (reported)

10

Locations

1 country

Sites

1

Timeline

Study Start

February 10, 2026

Actual (reported)

Primary Completion

February 13, 2026

Actual (reported)

Study Completion

February 13, 2026

Actual (reported)

Brief Summary

Background: Propofol is a drug that helps people fall asleep quickly and stay asleep during surgery, so they do not feel any pain. This drug is also used to sedate critically ill people who must be on a ventilator (a machine to help them breathe). To better understand how to interpret blood tests in these ill people, researchers need to know more about how the drug itself may change proteins in the blood. Objective: To collect blood samples from people before and after propofol is administered for surgery. Eligibility: People aged 18 years or older who are scheduled for surgery that requires sedation with propofol. Design: Participants will have data collected. This data will include age, sex, and ethnicity. They will be asked about their medical history. Participants will have blood samples collected before and after they receive propofol for their surgery. The blood will be collected from lines already installed for the surgery; no new needlesticks will be done for the study. A total of 3 teaspoons of blood will be drawn. The samples will be compared to each other to look for any changes caused by the drug. No follow-up visits are required.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 10 participants
Study completion date: February 13, 2026
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

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Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
December 19, 2025
Actual (reported)
First Posted
December 22, 2025
Actual (reported)
Study Start
February 10, 2026
Actual (reported)
Primary Completion
February 13, 2026
Actual (reported)
Study Completion
February 13, 2026
Actual (reported)

Last Updated: April 21, 2026
Status Verified: April 17, 2026
Last Update Submitted: April 18, 2026

Conditions

Critically Ill Surgical Patients

Keywords

PropofolBlood ProteomeBiomarkers

Outcome Measures

Primary Outcomes (1)

The primary endpoint of this study is the reproducibility measurements based on the repeated quantifications of biomarkers using different biomarkers assays pre- and post-propofol.
The investigators would like to use the O-link Explore HT and SomaScan Discovery v4.1assay on samples from participants who are critically ill. In order to do this understanding, the impact of propofol on each analyte must be understood as there is potential for interference with propofol in each sample.
1 year

Study Arms (1)

Critically ill surgical patients

Participant consented for a surgical procedure (primary surgical protocol) anticipated to require induction with propofol.

Eligibility Criteria

Age18 Years - 100 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Participant consented for a surgical procedure (primary surgical protocol) anticipated to require induction with propofol. Male or female aged 18 years or older.

You may qualify if:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

Sponsors & Collaborators

National Institutes of Health Clinical Center (CC)
NIHlead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Study Officials

Andrew J Mannes, M.D.
National Institutes of Health Clinical Center (CC)
PRINCIPAL INVESTIGATOR

Enrollment

10 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Sponsor Type: NIH
Responsible Party: SPONSOR

Study Record Dates

First Submitted

December 19, 2025

First Posted

December 22, 2025

Study Start

February 10, 2026

Actual (reported)

Provision of signed and dated informed consent form

Participant consented for a surgical procedure (primary surgical protocol) anticipated to require induction with propofol.

Male or female aged 18 years or older.

Ability of subject to understand and the willingness to sign a written informed consent document.

You may not qualify if:

Surgical procedure not utilizing propofol
Hemoglobin \< 7 ug/dL at the time of enrollment
Inability to sign consent

Contact the study team to confirm eligibility.

Primary Completion

February 13, 2026

Actual (reported)

Study Completion

February 13, 2026

Actual (reported)

Last Updated

April 21, 2026

Record last verified: 2026-04-17

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT07295795
Data provider: ClinicalTrials.gov
Source updated: 2026-04-21
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:21:10 UTC

Locations

US(1)

Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Critically ill surgical patients

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Critically ill surgical patients

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations