Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block

NCT07295184 | Recruiting

• 1 other identifier: Rebound pain
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs. The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden. Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.

Conditions

Rebound Pain Impact After Hip Surgery With Nerve Block

Outcome Measures

Primary Outcomes (1)

• Incidence of delirium

  The incidence of delirium will be evaluated in the first 72 hours postoperatively in the intensive care unit.

  72 hours

Interventions

Peripheral nerve block applied OTHER

Pericapsular Nerve Group block and the supra-inguinal fascia iliaca block applied

Only multimodal analgesia applied OTHER

Postoperative analgesia (paracetamol 1000 mg intravenously every 8 hours and celecoxib 200 mg orally every 12 hours)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We conducted a pilot study on 20 patients using the 'goodness-of-fit tests: contingency tables' test with G Power software. In our study, the incidence of rebound pain was 40%, and postoperative delirium developed in 50% of patients with rebound pain, compared to 8.3% in patients without rebound pain. Based on these data, an effect size of 0.356 was found, and an analysis was conducted using α=0.05, 90% power. The sample size was calculated as 83 patients. Considering the dropout rate, a total of 90 patients (36 patients with rebound pain and 54 patients without rebound pain) were calculated to be included in the study.

You may qualify if:

• Patients aged 18-80
• ASA I-III risk groups
• Undergoing elective hip surgery

You may not qualify if:

• Preoperative history of delirium, dementia, or major neurological disease
• Present cognitive impairment or severe hearing or visual impairment that could affect pain assessment
• Development of mechanical ventilation requirement in the intensive care unit; Need for bilateral hip surgery
• Failure to provide meaningful analgesia after block application due to surgical pain outside the scope of the block
• Patient's inability to complete the pain diary during postoperative follow-up;
• Urgent hip surgery
• Voluntary failure to give consent or request to withdraw from the study.

Sponsors & Collaborators

• Konya City Hospital: lead

Study Sites (1)

Konya City Hospital

Konya, Karatay, 42100, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Hasan SENAY, M.D.

CONTACT

05055078822; hasansenay@msn.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist, Department of Intensive Care Unit, Konya City Hospital, M.D

Study Record Dates

• First Submitted: December 8, 2025
• First Posted: December 19, 2025
• Study Start: May 12, 2026
• Primary Completion (Estimated): December 25, 2026
• Study Completion (Estimated): December 25, 2026
• Last Updated: May 14, 2026

Record last verified: 2026-05

Locations

TU (1)