Construction and Clinical Validation Study of a Prediction Model for Depression After Ischemic Stroke

NCT07294274 | Recruiting DMC

• 1 other identifier: 20251114
• Study Type: observational
• Target: 488
• Locations: 1 country
• Sites: 1

Brief Summary

Post-stroke depression (PSD) is the most common neuropsychiatric disorder after a stroke, with an incidence rate of 20% to 60%. PSD is not only associated with higher mortality rates, poorer recovery, more obvious cognitive impairments, greater economic burdens, and lower quality of life, but also brings additional medical expenses and care pressure to families. Society also needs to bear higher medical costs. Currently, the early diagnosis of PSD is difficult, which may lead to poor prognosis after stroke. This study aims to utilize machine learning technology to integrate multi-dimensional indicators of patients with ischemic stroke, establish a risk prediction model for PSD, and assist in early, accurate, and individualized assessment of PSD risk in clinical practice.

Conditions

Post-stroke Depression

Outcome Measures

Primary Outcomes (1)

• The number of post-stroke depression (PSD) that occurs 3 months after stroke

  3 months after stroke

Study Arms (2)

The group of PSD

The patient was diagnosed with PSD.

Diagnostic Test: Group patients based on whether they have been diagnosed with PSD.

NPSD

The patient was not diagnosed with PSD.

Diagnostic Test: Group patients based on whether they have been diagnosed with PSD.

Interventions

Group patients based on whether they have been diagnosed with PSD. DIAGNOSTIC_TEST

Group patients based on whether they have been diagnosed with PSD.

NPSD; The group of PSD

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Acute ischemic stroke patients who may develop post-stroke depression

You may qualify if:

• Patients with acute ischemic stroke;
• Admission within 7 days of symptom onset;
• The patient and/or the family members sign a written informed consent form.

You may not qualify if:

• Confusion of consciousness,severe cognitive impairment, etc
• Individuals with a history of depression, schizophrenia, bipolar disorder, etc;
• Individuals unable to participate in neuropsychological examinations due to hearing im pairments, lack of coordination, or neurological deficits, including se vere aphasia.

Sponsors & Collaborators

• Min Su: lead
• Chongqing Traditional Chinese Medicine Hospital: collaborator

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

RECRUITING

Central Study Contacts

Yanping Zhang

CONTACT

86+15223049366; zhangyp8415@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Anesthesiology

Study Record Dates

• First Submitted: November 27, 2025
• First Posted: December 19, 2025
• Study Start: November 1, 2025
• Primary Completion (Estimated): July 20, 2026
• Study Completion (Estimated): July 20, 2026
• Last Updated: February 5, 2026

Record last verified: 2026-02

Locations

CN (1)