Halt Aging in Survivors of Blood Cancers
HALTAging-1
1 other identifier
interventional
180
1 country
1
Brief Summary
Older survivors of blood cancer are at a high risk of accelerated biological aging, which increases their risk of developing multiple aging-related conditions. Whereas physical exercise can improve overall health, older cancer survivors do not meet the recommended physical activity, highlighting the need to develop behavioral interventions to increase adherence. Several other knowledge gaps exist to implement exercise interventions in older survivors of blood cancer; the dose and duration of exercise necessary to slow biological aging in older blood cancer survivors remain unknown. To bridge these gaps in knowledge, we have designed a Phase 2 randomized control trial to test the effects of behavioral and exercise interventions on various outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Apr 2026
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 5, 2025
CompletedFirst Posted
Study publicly available on registry
December 18, 2025
CompletedStudy Start
First participant enrolled
April 9, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 25, 2032
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 25, 2033
July 1, 2026
December 1, 2025
6 years
December 5, 2025
June 29, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Percentage of participants who adhered to the exercise regimen at 6-months post enrollment.
Participants achieving at least 120 minutes per week of moderate-intensity aerobic exercise, measured using Polar heart rate monitor data and exercise diaries.
6 Months from start of program
Percentage of participants who adhered to the exercise regimen at 12-months post enrollment.
Participants achieving at least 120 minutes per week of moderate-intensity aerobic exercise, measured using Polar heart rate monitor data and exercise diaries to assess sustainability of adherence.
12 Months from start of program.
Secondary Outcomes (1)
Physical Function (6- Minute Walk Test Distance)
6 months from randomization
Other Outcomes (7)
Physical Function Maximal Oxygen Consumption (VO₂ max)
6 months from randomization
Neuro-QOL Cognition Function Short Form Score
6 months from randomization
Trail Making Test Performance
6 months from randomization
- +4 more other outcomes
Study Arms (2)
Intervention Arm: Exercise + Behavioral Coaching
EXPERIMENTALIntervention arm incorporating virtually supervised moderate-intensity aerobic exercise and behavioral intervention/coaching to improve adherence
Enhanced Usual Care-Virtual Gym
ACTIVE COMPARATORParticipants will receive access to a virtual exercise platform, and educational sessions but will not receive behavioral coaching
Interventions
Intervention arm incorporating virtually supervised moderate-intensity aerobic exercise and behavioral intervention/coaching to improve adherence
Access to a virtual exercise platform that provides exercise classes and educational sessions for older survivors of blood cancer
Eligibility Criteria
You may qualify if:
- Age ≥50 years
- A history of hematological malignancy
- Participants must be able to and willingly give informed consent
You may not qualify if:
- Patients receiving intensive induction or consolidation chemotherapy. Maintenance chemotherapy, or lower-intensity chemotherapy for an indolent hematological malignancy is allowed.
- Neurodegenerative disease (e.g. Alzheimer's dementia), stroke, or uncontrolled psychotic disorders (e.g. schizophrenia or bipolar disorder) in the past 3 months if those disorders are considered significant enough to impair participation in the study.
- Illnesses such as clinical evidence of decompensated heart failure, unstable angina, or orthopedic or neuromuscular disorders that could limit safe participation in aerobic exercise.
- Cardiopulmonary exercise test results that preclude safe exercise (e.g., life-threatening arrhythmia, balance difficulties, peak VO2 \<10 ml/kg/min).
- Estimated life expectancy of less than 6 months (that precludes assessment of study primary endpoint).
- Self-reported pregnancy or the possibility of pregnancy.
- Participants who do not plan to follow up at the participating center.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Nebraska Medical Center
Omaha, Nebraska, 68008, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Vijaya Raj Bhatt, MBBS,MS
University of Nebraska
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 5, 2025
First Posted
December 18, 2025
Study Start
April 9, 2026
Primary Completion (Estimated)
March 25, 2032
Study Completion (Estimated)
March 25, 2033
Last Updated
July 1, 2026
Record last verified: 2025-12
Data Sharing
- IPD Sharing
- Will not share