Sensorimotor Integration in Patients With Tourette Syndrome

NCT07290920 | Completed

• 1 other identifier: ISM_L3053
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The present study investigates the mechanisms underlying the sense of agency in patients with Tourette Syndrome (TS). Previous research has shown that individuals with TS display impairments in both explicit and implicit aspects of agency, possibly due to altered integration between sensory feedback and motor predictions. To explore this hypothesis, the study will examine the phenomenon of sensory attenuation, a marker of sensorimotor integration that has not yet been investigated in this population. Furthermore, the study will assess how alterations in sensorimotor integration are related to the severity of TS symptoms.

Conditions

Sensory Gating; Tourette Disorder

Keywords

Tourette Syndrome; Sense of agency; Sensorimotor integration; Sensory attenuation; Motor control; Predictive processing

Outcome Measures

Primary Outcomes (1)

• Magnitude of sensory attenuation (difference between self-generated and externally generated force reproduction)

  Sensory attenuation

  Day 1

Study Arms (2)

Tourette Syndrome Patients

Patients affected by Tourette Syndrome

Healthy controls

Individuals without neurological or psychiatric disorders

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include adult participants aged 18 to 65 years, comprising two groups: individuals diagnosed with Tourette Syndrome (TS) and healthy control participants. The Tourette group will consist of patients meeting DSM-5 diagnostic criteria for Tourette Syndrome, recruited through specialized neurological and neuropsychiatric clinics. Healthy controls will be recruited from the general population and will be matched to the TS group for age, sex, and education level.

You may qualify if:

• For Tourette Syndrome group:
• Clinical diagnosis of Tourette Syndrome (TS) according to DSM-5 criteria
• Age between 18 and 65 years
• Ability to understand and comply with study procedures
• Written informed consent provided
• For Healthy Control group:
• No current or past history of neurological or psychiatric disorders
• Age between 18 and 65 years
• Matched to the TS group for age, sex, and education level
• Ability to understand and comply with study procedures
• Written informed consent provided

You may not qualify if:

• History of significant neurological disorders (e.g., brain injury or dementia) or major psychiatric disorders (with the exception of conditions commonly associated with Tourette Syndrome, such as Obsessive-Compulsive Disorder, ADHD, depression, and anxiety);
• Failure or refusal to provide written informed consent;
• Confirmed pregnancy (self-reported) and/or breastfeeding.

Sponsors & Collaborators

• I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio: lead

Study Sites (1)

IRCCS Ospedale Galeazzi-Sant'Ambrogio

Milan, Italy, 20100, Italy

Location

Related Publications (3)

• Delorme C, Salvador A, Voon V, Roze E, Vidailhet M, Hartmann A, Worbe Y. Illusion of agency in patients with Gilles de la Tourette Syndrome. Cortex. 2016 Apr;77:132-140. doi: 10.1016/j.cortex.2016.02.003. Epub 2016 Feb 17.

  PMID: 26963083 BACKGROUND

• Zapparoli L, Seghezzi S, Zirone E, Guidali G, Tettamanti M, Banfi G, Bolognini N, Paulesu E. How the effects of actions become our own. Sci Adv. 2020 Jul 1;6(27):eaay8301. doi: 10.1126/sciadv.aay8301. Print 2020 Jul.

  PMID: 32937445 BACKGROUND

• Brown H, Adams RA, Parees I, Edwards M, Friston K. Active inference, sensory attenuation and illusions. Cogn Process. 2013 Nov;14(4):411-27. doi: 10.1007/s10339-013-0571-3. Epub 2013 Jun 7.

  PMID: 23744445 BACKGROUND

MeSH Terms

Conditions

Tourette Syndrome

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2025
• First Posted: December 18, 2025
• Study Start: March 20, 2025
• Primary Completion: December 3, 2025
• Study Completion: December 3, 2025
• Last Updated: December 18, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)