Comparing CCI and POSSUM for Predicting Oncogynecologic Surgery Complications

NCT07287280 | Recruiting DMC

• 2 other identifiers: 339/2568(IRB4)Si 428/2025
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

With the global rates of gynecologic cancers on the rise, optimizing perioperative care is imperative. Accurate risk prediction is essential for enhancing patient care, directing preoperative interventions, and facilitating informed decision-making in oncology. This research compares two widely-used risk assessment tools: the Charlson Comorbidity Index (CCI) and the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM), in predicting perioperative outcomes. The CCI predominantly addresses comorbidities, providing simplicity and broad applicability, while POSSUM incorporates both physiological and operative factors for a more comprehensive risk assessment. Despite their application across various surgical specialties, the specific utility of these tools in onco-gynecologic surgery remains insufficiently explored. The study aims to evaluate the effectiveness of CCI and POSSUM in predicting perioperative complications, with a focus on the incidence of these complications, length of hospital stay, and 30-day mortality. The implementation of these risk tools may enhance multidisciplinary risk management, thus improving patient outcomes in gynecologic oncology surgery.

Conditions

Gynecologic Surgical Procedures; Risk Assessment; Perioperative Care

Keywords

Gynecologic oncology surgery; Perioperative complications; Charlson comorbidity index; POSSUM; Mortality

Outcome Measures

Primary Outcomes (1)

• Comparison of CCI and POSSUM to predict perioperative complications

  To compare the prediction of perioperative anesthetic and surgical morbidity by the Charlson-Comorbidity Index versus POSSUM score in patients undergoing elective onco-gynecological surgery

  from the date of starting surgery to the date of hospital discharge, up to 30 days

Secondary Outcomes (11)

• Intraoperative hypotension

  Within 24 hours from starting of surgery

• Quantity of intraoperative blood loss

  Within 24 hours from starting of surgery

• Rate of blood transfusion

  Within 24 hours from starting of surgery

• Rate of vasopressor usage

  from the time staring of surgery to the time of finishing surgery, up to 12 hours

• Clavian-Dindo classification of surgical complications

  from the date of starting surgery to the date of hospital discharge, up to 30 days

Interventions

CCI score OTHER

Charlson comorbidity index included age and medical conditions

Also known as: Charlson comorbidity index

POSSUM score OTHER

POSSUM included physical status and laboratory investigation

Also known as: Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient aged \>,= 18 years, underwent elective onco-gynecologic surgery.

You may qualify if:

• Age \> 18 years
• Patient underwent elective onco-gynecologic surgery

You may not qualify if:

• Patient required emergency surgery from any indication
• Patient chart that not contained primary outcome data eg. absent of the anesthetic record

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand

RECRUITING

MeSH Terms

Interventions

Morbidity

Intervention Hierarchy (Ancestors)

Vital Statistics; Data Collection; Epidemiologic Methods; Investigative Techniques; Demography; Population Characteristics; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• Patchareya Nivatpumin, M.D.

  Department of Anesthesiology, Faculty of Medicine Siriraj Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Patchareya Nivatpumin, M.D.

CONTACT

+66896662187; patchareya.niv@mahidol.ac.th

Jitsupa Nithiuthai, M.D.

CONTACT

+66654536516; jitsupa.nithiuthai@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 23, 2025
• First Posted: December 17, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): October 31, 2027
• Last Updated: December 17, 2025

Record last verified: 2025-12

Locations

TH (1)