Mindfulness Walking Intervention to Enhance Resilience (iWalk)

NCT07285954 | Recruiting

• 1 other identifier: IRB25-0202
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a randomized controlled trial of the walking meditation intervention (iWalk) program, a multi-component intervention integrating walking meditation, education, and group sessions designed to enhance resilience in individuals with multiple sclerosis (MS). The objectives are to evaluate:

1. 1.Recruitment capability and retention rates,
2. 2.Acceptability and adherence to the intervention,
3. 3.Feasibility of assessment procedures, and
4. 4.Preliminary effects on psychological, physiological, and behavioral outcomes.

Conditions

Neurodegenerative Disease; EEG; Mindfulness; Adults

Keywords

Walking meditation; Emotional regulation; EEG

Outcome Measures

Primary Outcomes (6)

• Connor Davidson Resilience Scale for Adults (CD-RISC 25)

  The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.

• Multiple Sclerosis Resilience Scale (MSRS)

  The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.

• Stroop Task

  The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.

• Symbol Digit Modalities Test

  The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.

• Wisconsin Card Sorting Test

  The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.

• Sustained Attention to Response Task

  The baseline means assessments done two weeks before the intervention start date. Post-intervention assessments will be conducted two weeks after the intervention. Follow-up 1 is 24 weeks from baseline, and follow-up 2 is 48 weeks from baseline.

Study Arms (3)

iWalk Program

ACTIVE COMPARATOR

This group receives the complete iWalk program.

Behavioral: iWalk Program

Education Only without Walking Mindfulness Practice

ACTIVE COMPARATOR

This group receives only education part of the iWalk program without walking mindfulness sessions.

Behavioral: iWalk Program

Control Group

NO INTERVENTION

This group does not receive any intervention and are placed on a waiting list.

Interventions

iWalk Program BEHAVIORAL

A multi-component behavioral program integrating walking meditation, education, and group sessions to enhance resilience and stress regulation in adults with and without chronic conditions.

Education Only without Walking Mindfulness Practice; iWalk Program

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years or older,
• clinical diagnosis of a neurodegenerative disease such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, stroke, etc.,
• have not practiced meditation regularly (e.g., 10 mins per day) and have never attended any meditation classes or community programs,
• never received meditation training via coaching/certification/life coaching,
• have internet access,
• with no severe cognitive impairment, i.e., have a score of ≥ 21 on Modified Telephonic Interview for Cognitive Status (TICS-M),
• be able to walk with or without an assistive device (Patient determined Disease Steps score ranged from 0-6),
• are willing to be randomized to an intervention or a control group,
• are willing to wear Fitbit (a wrist smart watch) for eight weeks,
• are individuals who are right-handed according to the Edinburgh Handedness Questionnaire,
• are willing to participate in all assessments, including in-person testing using electroencephalography (EEG) and cognitive tests, online survey/questionnaires, and online interviews or focus group discussions,
• are willing to wear a Hexoskin t-shirt, which is a heart rate variability monitor, while doing the assessments in person.

You may not qualify if:

• Participants who cannot speak, read, write, or listen in English.

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead

Study Sites (1)

University of Illinois Urbana-Champaign

Urbana, Illinois, 61801, United States

RECRUITING

MeSH Terms

Conditions

Neurodegenerative Diseases; Emotional Regulation

Condition Hierarchy (Ancestors)

Nervous System Diseases; Self-Control; Social Behavior; Behavior

Central Study Contacts

Chung-Yi Chiu

CONTACT

12172446435; chiucy@illinois.edu

Vaishnavi Sridharan

CONTACT

vs35@illinois.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: October 16, 2025
• First Posted: December 16, 2025
• Study Start: June 1, 2025
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: December 16, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)