Impact of Capillaroscopy in the Investigation of Diffuse Interstitial Pneumonias

NCT07283081 | Recruiting

• 1 other identifier: CHUBX 2025/086
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesize that in patients with a new diagnosis of Pulmonary Interstitial Disease (PID), adding capillaroscopy to standard care increases the proportion of patients receiving a diagnosis of PID-Connective Tissue Disease (PID-CTD) within the first three months of follow-up, thereby reducing the time to diagnosis and facilitating the implementation of appropriate treatment as quickly as possible. Therefore, To confirm this hypothesis, it is necessary to know the characteristics of capillaroscopy in patients with a new diagnosis of PID.

Conditions

Interstitial Lung Disease; Connective Tissue Diseases

Keywords

Pulmonary Interstitial Disease; capillaroscopy; Connective Tissue Disease; diagnosis

Outcome Measures

Primary Outcomes (1)

• Proportion of capillaroscopy abnormalities according to the classification proposed by the EULAR Study Group on Microcirculation in Rheumatic Diseases

  At baseline (Day 0)

Secondary Outcomes (4)

• Description of the criteria that may influence the results of capillary examination: proportion of smoking status categories (active smoker/non-smoker/former smoker) and number of cigarettes per day for active smokers

  At baseline (Day 0)

• Description of the criteria that may influence the results of capillary examination: number of cigarettes per day for active smokers

  At baseline (Day 0)

• Description of the criteria that may influence the results of capillary examination: proportion of patients who consume alcohol

  At baseline (Day 0)

• Description of the criteria that may influence the results of capillary examination: average number of standard drinks for active consumers.

  At baseline (Day 0)

Study Arms (1)

Diffuse interstitial lung diseases (DILD)

EXPERIMENTAL

Diagnostic Test: capillaroscopy

Interventions

capillaroscopy DIAGNOSTIC_TEST

Capillaroscopy will be performed during a specific consultation. During this examination, a device called a "video capillaroscope" is used to magnify and visualize the capillaries located at the base of the nail. The examination lasts approximately twenty minutes.

Diffuse interstitial lung diseases (DILD)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female over 18 years of age;
• Have received a new diagnosis of PID within the last six months, confirmed by a pulmonologist;
• Have undergone some specific tests within the last six months (Chest CT scan, respiratory function tests (plethysmography and CO transfer capacity measurement, immunological assessment including: screening for FAN, FR, and anti-CCP);
• French-speaking patient with no comprehension difficulties;
• Person affiliated with or beneficiary of a social security system;

You may not qualify if:

• Have previously undergone a capillaroscopy, regardless of the reason;
• Have a diagnosis or high suspicion of connective tissue disease based on initial clinical and paraclinical evaluation;
• Have already started one of the following treatments for pulmonary involvement: systemic corticosteroids, immunosuppressive therapy, antifibrotic therapy;
• Pregnant or breastfeeding women;
• Patients covered by Articles L 1121-5 to L 1121-8 (persons deprived of their liberty by judicial or administrative decision, minors, adults subject to legal protection measures, or persons unable to give their consent).

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

CHU de Bordeaux - service de rhumatologie

Bordeaux, France

RECRUITING

MeSH Terms

Conditions

Lung Diseases, Interstitial; Connective Tissue Diseases; Disease

Interventions

Microscopic Angioscopy

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Skin and Connective Tissue Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Intravital Microscopy; Microscopy; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Cardiovascular; Investigative Techniques

Study Officials

• Marie-Elise TRUCHETET, MD, PhD

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Marie-Elise TRUCHETET, MD, PhD

CONTACT

05.56.79.55.56; marie-elise.truchetet@chu-bordeaux.fr

Thomas BARNETCHE, PhD

CONTACT

thomas.barnetche@chu-bordeaux.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2025
• First Posted: December 15, 2025
• Study Start: March 16, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: March 20, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)