Metabolomics in the Diagnosis and Treatment of Asthma in Children

NCT07280364 | Recruiting

• 1 other identifier: 03-24
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the metabolomic profile of blood and urine in children 12-17 years with asthma. The main question it aims to answer is: • Are there metabolites in the blood and urine that are specific for asthma exacerbation? Participants already receive standard therapy as part of their regular medical care for asthma.

Conditions

Asthma

Keywords

bronchial asthma; children; metabolomics; metabolites

Outcome Measures

Primary Outcomes (1)

• inflammation biomarkers

  Identification of metabolomic changes (inflammation biomarkers) in the blood (aminoacids) and urine (organic acids) of patients with mild, moderate, and severe bronchial asthma associated with asthma exacerbation.

  baseline and 10 days

Secondary Outcomes (1)

• metabolomic changes

  baseline and 10 days

Interventions

Standart medical treatment DRUG

No intervention, patients will recieve standard medical treatment

Eligibility Criteria

• Age: 12 Years - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The study will include children hospitalized in the pulmonology department of the Sechenov Center for Maternity and Childhood Care at Sechenov University.

You may qualify if:

• Age from 12 to 17 years old
• Confirmed diagnosis of asthma
• Informed voluntary consent to participate in the study

You may not qualify if:

• age under 12 years
• no established diagnosis of asthma
• concomitant severe somatic, metabolic, and endocrine diseases
• patient's withdrawal of informed consent

Sponsors & Collaborators

• I.M. Sechenov First Moscow State Medical University: lead

Study Sites (1)

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Moscow, Russia

RECRUITING

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Natalia A. Geppe, MD, Doctor of M.Sc., Professor

  I.M. Sechenov First Moscow State Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Natalia A. Geppe, MD, Doctor of M.Sc, Professor

CONTACT

+7-499-248-44-22; geppe@mail.ru

Irina V. Ozerskaia, MD, PhD

CONTACT

+7-926-387-25-12; ozerskaya_i_v@staff.sechenov.ru

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 1, 2025
• First Posted: December 12, 2025
• Study Start: March 13, 2024
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: January 28, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

RU (1)