Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity

NCT07278245 | Completed

• 2 other identifiers: 23-318ID-RCB Number: 2025-A01589-40
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation. In particular, it will analyze fine motor control, autonomic nervous system regulation and metabolic responses. To this end, the study will compare two groups during a pointing exercise in a centrifuge (hypergravity). One group will have been trained to do this exercise using an exoskeleton, while the other will have been familiarized with the task without the exoskeleton. It will assess whether the exoskeleton can be an effective and accessible training tool for astronauts.

Conditions

Motor Learning and Physiological Adaptation

Outcome Measures

Primary Outcomes (1)

• Task performance (movement accuracy)

  Task performance (movement accuracy) is defined as the difference between the position touched on the screen and the position of the displayed target. The participants will be required to perform an aiming movement task using their right arm, directed toward a target.The participants will need to point to the center of the displayed target.

  From familiarisation sessions (Day 1 to Day 4) to testing day at Day 5.

Study Arms (2)

Control

NO INTERVENTION

Untrained group

Trained

EXPERIMENTAL

Trained with the exoskeleton

Other: Training with an exoskeleton

Interventions

Training with an exoskeleton OTHER

Training to perform an aiming task under simulated hypergravity via an exoskeleton

Trained

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Maximum weight of 90 kg
• Maximum sitting butt-to-shoulder distance of 70 cm
• Certified as healthy by a comprehensive clinical assessment
• Normal or corrected to normal vision
• Right-handed tested with Edinburgh-Handedness-Inventory-Test (≥6th percentile, on https://www.brainmapping.org/shared/Edinburgh.php)
• Non smokers
• No alcohol or drug dependence, no medical treatment on a regular basis
• Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC) or a Global Health Insurance Card (GHIC).
• Free of any engagement during the study
• Test subjects must be able to understand and speak English
• Who agreed to take part in the study and signed the informed consent

You may not qualify if:

• Left-handed tested with Edinburgh-Handedness-Inventory-Test (\<6th percentile)
• Subjects with experience in experiments on a short arm human centrifuge or under real hyper-gravity
• Non-tolerance to the centrifugation
• Any history or presence of clinically relevant chronic disease
• Refusal to give permission to contact his general practitioner,
• Subject who, in the judgment of the investigator, is likely to be non-compliant during the study, or unable to cooperate because of a language problem or poor mental development,
• Subject who has received more than 6000 Euros within 12 months for being a research subject,
• Subject who cannot be contacted in case of emergency,
• Vulnerable people according to law "Code de la Santé Publique" (L1121-5 to L1121-8)

Sponsors & Collaborators

• MEDES Institut de Médecine et de Physiologie Spatiales, Toulouse: collaborator
• Centre National d'Etudes Spatiales: lead

Study Sites (1)

Medes - Imps

Toulouse, Occitanie, 31400, France

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 25, 2025
• First Posted: December 12, 2025
• Study Start: October 27, 2025
• Primary Completion: November 27, 2025
• Study Completion: January 27, 2026
• Last Updated: February 5, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)