Analysis of The Outcomes of Therapeutic Photorefractive Keratectomy Combined With Prophylactic Accelerated Cross-Linking (PRK-Plus), for Treatment of Thin Suspicious Cornea

NCT07277348 | Not Yet Recruiting

• 1 other identifier: PRK PLUS in thin cornea
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

analyze the outcomes of therapeutic photorefractive keratectomy combined with prophylactic accelerated cross-linking (PRK-Plus), for treatment of thin suspicious cornea

Conditions

Thin Suspicious Cornea

Outcome Measures

Primary Outcomes (1)

• visual acuity improvement measured by LogMAR system

  visual acuity improvement measured by LogMAR system

  1 year

Study Arms (2)

PRK PLUS

EXPERIMENTAL

PRK PLUS

Procedure: PRK PLUS

Follow up group

NO INTERVENTION

follow up with pentacam

Interventions

PRK PLUS PROCEDURE

therapeutic photorefractive keratectomy combined with prophylactic accelerated cross-linking

PRK PLUS

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• CCT less than 490 microns
• K mean more than 46 and/or K max more than 47.
• Astigmatism cylinder \>1.5 D.
• D value of Belin/Ambrósio Module \> 1.6
• inferior- superior asymmetry or bow-tie pattern with skewed radial axes on tangential maps and abnormal changes on (BAD).
• Asymmetry topography between 2 eyes, even if neither eye"s topographic pattern is in itself decidedly abnormal.
• Any significant skewed radial axis with or without inferior steepening, or one diopter or more of inferior steepening in some areas but an I-S value of ,1.4,7.
• young patients with against-the-rule astigmatic patterns.
• a PTA value 40% if calculated.
• Abnormal Topographic Patterns
• K2 reading of corneal back surface less than \[-7\].
• D Value of CSTP \> 2.5 in Belin/Ambrósio curve
• We look at values within the central 5 mm circle; the map should be displayed in the BFTE float mode with an estimated area of 8 mm of diameter:
• Elevation values on the front surface values \> +12 μ
• Elevation values on the back surface values \>+15 μ.

You may not qualify if:

• Eyes diagnosed with KC.
• CCT less than 450 microns

Sponsors & Collaborators

• Fayoum University: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: November 28, 2025
• First Posted: December 11, 2025
• Study Start: February 1, 2026
• Primary Completion (Estimated): January 31, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: December 11, 2025

Record last verified: 2025-11