Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy

NCT07276646 | Recruiting

• 1 other identifier: 1783
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the analgesic effect of retro superior costotransverse ligament space block vs erector spinae plane block to Achieve high-quality perioperative opioid-sparing effect and postoperative analgesia after laparoscopic cholecystectomy with optimum hemodynamic stability and high patient and surgeon satisfaction

Conditions

Perioperative Analgesia

Keywords

retrosuperior costotransverse ligament block; erector spinae block; laparoscopic cholecystectomy

Outcome Measures

Primary Outcomes (1)

• The time to first call to rescue analgesia

  The time to first call to rescue analgesia( the interval between the block injection till the NRS more than or equal 4) (naluphine) will be recorded

  24 hours

Secondary Outcomes (7)

• To assess block characteristics (block performance time)

  1 hour

• Total intraoperative fentanyl consumption

  duration of surgery (up to 2 hours)

• Pain intensity by Numerical Rating Scale

  30 minutes after arrival to post anesthesia care unit , 2hours, 4hours, 6hours, 8hours, 12hours, 18 hours and 24hours postoperative

• total amount of rescue analgesia

  24 hours

• Intraoperative hemodynamics (Heart Rate and Mean Arterial Pressure)

  every 5 minutes in the first 30 minutes then every 10 minutes till the end of surgery

Study Arms (2)

Retrosuperior costotransverse ligament block group

ACTIVE COMPARATOR

The patient will receive retrosuperior costotransverse ligament block

Procedure: Retrosuperior costotransverse ligament block group

Erector spinae block group

ACTIVE COMPARATOR

The patient will receive erector spinae block.

Procedure: Erector spinae block group

Interventions

Retrosuperior costotransverse ligament block group PROCEDURE

The patient will receive retrosuperior costotransverse ligament block

Retrosuperior costotransverse ligament block group

Erector spinae block group PROCEDURE

The patient will receive erector spinae block.

Erector spinae block group

Eligibility Criteria

• Age: 21 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• patient acceptance
• Age: 21-64 years old.
• Sex: both sexes.
• Physical status: ASA I \& II.
• Body mass index (BMI): 18.5 - 30 kg/m2.
• Type of operations: elective laparoscopic cholecystectomy.
• Duration of surgery not more than 2 hours.

You may not qualify if:

• Known hypersensitivity to lidocaine or bupivacaine.
• Patients with respiratory insufficiency.
• Coagulation disorders or taking drugs affect surgical hemostasis.
• \. Patients with pre-existing neurological deficits. 8. Uncooperative patient or with altered mental status. 9. Patient with advanced cardiovascular or respiratory diseases

Sponsors & Collaborators

• Zagazig University: lead

Study Sites (1)

Faculty of human medicine, Zagazig university, Zagazig

Zagazig, Egypt

RECRUITING

Central Study Contacts

Dina Salem, MD

CONTACT

01099333513

Marwa Medhat, MD

CONTACT

01002828937

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: anesthesiologist not sharing in the study will assess outcomes
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Model Details: Achievement of high-quality perioperative opioid-sparing effect and postoperative analgesia for laparoscopic cholecystectomy with optimum hemodynamic stability and high patient and surgeon satisfaction by comparing retrosuperior costotransverse ligament block and erector spinae block in laparoscopic cholecystectomy

Study Record Dates

• First Submitted: November 29, 2025
• First Posted: December 11, 2025
• Study Start: December 10, 2025
• Primary Completion (Estimated): June 10, 2026
• Study Completion (Estimated): July 10, 2026
• Last Updated: December 12, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)