Association Between SYNTAX Score and Leukoglycemic Index In Patients Wiht Acute Coronary Syndrome

NCT07276256 | Completed Results

• 1 other identifier: 2024.05.19
• Study Type: observational
• Target: 552
• Locations: 1 country
• Sites: 1

Brief Summary

This study looks at people who come to the hospital with acute coronary syndrome, a serious heart condition. When these patients first arrive, doctors take routine blood tests. The investigators use these test results to calculate a value called the leukoglycemic index (LGI), which combines white blood cell count and blood sugar level. The investigators also use a heart imaging score called the SYNTAX score to see how complex their coronary artery disease is. Patients are divided into two groups based on their SYNTAX scores: one group with lower scores (22 or less), and one with higher scores (above 22). The investigators compare their health data to see if LGI is linked to the severity of their heart disease. The investigators also check if LGI can help predict how complex the disease is. Information like age, family history, and chronic illnesses is collected from patient records and medical interviews.

Conditions

Acute Coronary Syndromes (ACS)

Keywords

Acute coronary syndrome; Coronary artery disease; inflammation; risk stratification; SYNTAX score; leukoglycemic index

Outcome Measures

Primary Outcomes (1)

• Leukoglycemic Index (LGI)

  The LGI is calculated as the product of blood glucose concentration (mg/dL) and leukocyte count (cells/mm³). This composite measure provides a single numerical value that reflects both metabolic status (via blood glucose) and hematological status (via white blood cell count). At baseline, LGI serves as an integrated indicator of participants' metabolic and immune activity. It is simple to compute and offers a practical way to capture two fundamental aspects of health in one measure. Higher values are considered worse outcomes because they reflect an increased metabolic and inflammatory burden

  First day

Study Arms (2)

SYNTAX score =<22

Other: leukoglycemic index calculation

SYNTAX score >22

Other: leukoglycemic index calculation

Interventions

leukoglycemic index calculation OTHER

leukoglycemic index calculation

SYNTAX score =<22; SYNTAX score >22

Eligibility Criteria

• Age: 18 Years - 88 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute coronary syndrome

You may qualify if:

• Adult patients aged 18 years and older
• Patients who underwent coronary angiography due to acute coronary syndrome

You may not qualify if:

• Patients with diabetes mellitus (Diagnosis based on current use of oral antidiabetic or insulin therapy and/or fasting glucose level ≥126 mg/dL and HbA1c ≥6.5%)
• Patients with atrial fibrillation, history of pacemaker implantation, asthma, pulmonary hypertension, pregnancy, anemia, malignancy, rheumatoid arthritis, or peripheral artery disease
• Obese individuals (defined as body mass index \[BMI\] \>30 kg/m²)
• Patients whose medical records could not be accessed

Sponsors & Collaborators

• Kırıkkale University: lead

Study Sites (1)

Kırıkkale university

Kırıkkale, Kırıkkale, 71000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Acute Coronary Syndrome; Coronary Artery Disease; Inflammation

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Coronary Disease; Arteriosclerosis; Arterial Occlusive Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Limitations and Caveats

There was no limitation about the study

Results Point of Contact

• Title: Rukiye GONEN OZDEMIR
• Organization: Kırıkkale University, Faculty of Medicine, Department of Cardiology

rukiye_gonen@hotmail.com

05054503953

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical doctor

Study Record Dates

• First Submitted: November 28, 2025
• First Posted: December 11, 2025
• Study Start: September 24, 2025
• Primary Completion: October 21, 2025
• Study Completion: October 21, 2025
• Last Updated: February 25, 2026
• Results First Posted: February 25, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)