End-to-Side Interrupted Versus Continuous Arterial Suturing in Living Donor Kidney Transplantation

NCT07274943 | Not Yet Recruiting

• 1 other identifier: Arterial suturing in kidney
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will compare two standard ways of stitching the kidney artery to the iliac artery in adults receiving a living donor kidney transplant. The two techniques are interrupted suturing and continuous suturing. The study will review past transplant cases and follow new patients at Assiut University Urology Hospital. For each patient, the team will record details of the operation, blood flow in the kidney artery, kidney function, and any surgical or vascular complications during the first three months after surgery. The main goals are to see whether one suturing pattern shortens cold ischemia time and improves early blood flow measurements, and to explore how these techniques affect early graft function, complication rates, and short-term graft and patient survival.

Conditions

Suture Techniques; Suture, Interrupted; Continuous Suture; Kidney Transplant

Keywords

donor kidney transplantation; end-to-side arterial suturing; iliac arteries

Outcome Measures

Primary Outcomes (2)

• Cold Ischemia Time

  Duration in minutes from the start of graft perfusion with cold preservation solution in the donor to arterial de-clamping in the recipient, compared between interrupted and continuous arterial suturing groups.

  From donor graft perfusion to arterial de-clamping during the transplant operation (single intraoperative measurement).

• Early Graft Arterial Blood Flow (Resistive Index and Systolic Velocity)

  Mean systolic blood flow velocity and resistive index of the transplanted kidney artery measured by Doppler ultrasound and compared between interrupted and continuous arterial suturing groups.

  Within the first 3 months after transplantation (assessments at approximately 1 week, 1 month, and 3 months post-transplant).

Study Arms (2)

Interrupted Arterial Suturing

Adult living donor kidney transplant recipients whose renal artery is anastomosed end-to-side to the external or common iliac artery using interrupted 6/0 Prolene sutures as part of standard surgical practice.

Continuous Arterial Suturing

Adult living donor kidney transplant recipients whose renal artery is anastomosed end-to-side to the external or common iliac artery using continuous 6/0 Prolene sutures as part of standard surgical practice.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study includes adult recipients of living donor kidney transplants performed at Assiut University Urology Hospital. Patients are selected based on having undergone or scheduled for living donor kidney transplantation, excluding those with end-to-end arterial suturing with the internal iliac artery, early acute rejection, or inadequate follow-up or data. Both retrospective cases and prospectively recruited patients with complete clinical, radiological, and laboratory data are included. The sample size is 70 patients divided equally between two arterial suturing technique groups.

You may qualify if:

• Adult patients undergoing living donor kidney transplantation at Assiut Kidney Transplantation Unit since November 2015

You may not qualify if:

• Patients undergoing end-to-end arterial suturing with internal iliac artery
• Patients with acute allograft rejection within the first post-transplant week
• Patients with follow-up shorter than 3 months after transplantation
• Patients with missing relevant preoperative or postoperative data
• Patients refusing participation

Sponsors & Collaborators

• Assiut University: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident at the Department of Urology, Assiut University

Study Record Dates

• First Submitted: November 28, 2025
• First Posted: December 10, 2025
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: December 10, 2025

Record last verified: 2025-11