Can Pretreatment With Analgesics Reduce Postendodontic Pain?

NCT07271654 | Completed

• 1 other identifier: SCD-EndoPain-2025
• Study Type: interventional
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial investigated whether a single dose of diclofenac sodium taken before a root canal procedure can reduce pain in the hours following the treatment. 160 patients with tooth pain from irreversible pulpitis were divided into two groups. One group received 100mg of diclofenac sodium 30 minutes before their procedure, while the other group received no pretreatment. Pain levels were measured at 6, 12, and 24 hours after the procedure. The study found that patients who took diclofenac before treatment were significantly more likely to be pain-free at 6 and 12 hours after the procedure compared to those who did not.

Conditions

Pulpitis - Irreversible

Keywords

Endodontic pain; NSAIDS; postoperative pain

Outcome Measures

Primary Outcomes (1)

• Incidence of Postendodontic Pain

  Proportion of patients reporting no pain, mild pain, moderate pain, or severe pain as measured on a Visual Analogue Scale (VAS

  6 hours after endodontic treatment

Secondary Outcomes (2)

• Incidence of Postendodontic Pain

  12 hours after endodontic treatment

• Incidence of Postendodontic Pain

  24 hours after endodontic treatment

Study Arms (2)

pre treatment with NSAIDS

EXPERIMENTAL

Experimental

Procedure: Pre treatment with NSAIDS; Procedure: No pretreatment with NSAIDS.

No pre treatment with NSAIDS

ACTIVE COMPARATOR

No pretreatment medication was administered before endodontic treatment.

Procedure: Pre treatment with NSAIDS; Procedure: No pretreatment with NSAIDS.

Interventions

Pre treatment with NSAIDS PROCEDURE

Single oral dose of 100 mg Diclofenac Sodium, administered 30 minutes prior to endodontic treatment.

No pre treatment with NSAIDS; pre treatment with NSAIDS

No pretreatment with NSAIDS. PROCEDURE

Single oral dose of 100 mg Diclofenac Sodium, administered 30 minutes prior to endodontic treatment.

No pre treatment with NSAIDS; pre treatment with NSAIDS

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Current use of prophylactic antibiotics.
• Pregnancy or lactation.
• Mental disabilities.
• Systemic illnesses contraindicating endodontic therapy.
• Known hypersensitivity or adverse reaction to NSAIDs.

Sponsors & Collaborators

• College of Physicians and Surgeons Pakistan: lead

Study Sites (1)

Saidu College of dentistry,Swat

Swat, Pakistan

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Anti-Inflammatory Agents, Non-Steroidal

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Analgesics, Non-Narcotic; Analgesics; Sensory System Agents; Peripheral Nervous System Agents; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Anti-Inflammatory Agents; Therapeutic Uses; Antirheumatic Agents

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postgraduate Resident, Department of Operative Dentistry

Study Record Dates

• First Submitted: November 26, 2025
• First Posted: December 9, 2025
• Study Start: August 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: December 9, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)