Moisturization and Skin Hydration Study

NCT07270965 | Not Yet Recruiting

• 1 other identifier: H25-02646
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Skin moisturization is important for patients with atopic dermatitis, commonly known as eczema. Moisturizing right after bathing is widely accepted as the best method to keep skin hydrated. However, there is conflicting research on the timing of moisturizing. The goal of this clinical study is to evaluate the preference of moisturizing while showering/bathing compared to after towel drying in adolescents aged 12-18 with eczema. The main question it aims to answer are:

• Which moisturization technique is preferred: while showering/bathing or after towel drying?
• How do these techniques affect investigator-assessed eczema severity, patient-reported itch scores, and objective skin hydration measurements? Researchers will compare applying moisturizer while in the shower/bath to after towel drying and to which technique is preferred among participants and if there are different effects on eczema and skin hydration. Participants will:
• Apply moisturizer while showering/bathing for one month and after towel drying for one month.
• Complete questionnaires on moisturization technique, skin feel, and itchiness.
• Undergo skin hydration measurements using a Corneometer® CM825 device.

Conditions

Atopic Dermatitis (Eczema); Atopic Dermatitis (AD)

Keywords

Atopic Dermatitis; Eczema; AD; Moisturizer; Cream; Skin Hydration

Outcome Measures

Primary Outcomes (1)

• Proportion of Participants Preferring Each Moisturization Technique

  Participant reported preference of moisturization technique

  Through study completion, an average of 2 months.

Secondary Outcomes (1)

• Skin Hydration Level

  Through study completion, an average of 2 months.

Other Outcomes (2)

• Eczema Severity Score

  Through study completion, an average of 2 months.

• Itch Intensity

  Through study completion, an average of 2 months.

Study Arms (2)

Moisturizing while in shower/bath

EXPERIMENTAL

Behavioral: Moisturizing while in shower/bath

Moisturizing after towel drying

EXPERIMENTAL

Behavioral: Moisturizing after towel drying

Interventions

Moisturizing while in shower/bath BEHAVIORAL

Applying moisturizer in the shower/bath.

Moisturizing while in shower/bath

Moisturizing after towel drying BEHAVIORAL

Applying moisturizer out of the shower/bath after towel drying.

Moisturizing after towel drying

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Participants must have a diagnosis of atopic dermatitis/eczema.
• Participants must be between the age of 12-18.
• Participants must be able to bathe independently.
• Participants will be English speaking and able to complete questionnaires.

You may not qualify if:

• Participants who use topical corticosteroids between one inch above the wrist and 1 inch below the elbow from 1 month on both arms prior to the study until the final visit.
• Participants who have a known allergy to the moisturizer cream (Cerave Moisturizing Cream) provided.

Sponsors & Collaborators

• L'Oreal: collaborator
• University of British Columbia: lead

Study Sites (1)

BC Children's Hospital

Vancouver, British Columbia, Canada

Location

MeSH Terms

Conditions

Dermatitis, Atopic; Eczema

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Central Study Contacts

Wingfield Rehmus, MD, MPH

CONTACT

1-604-875-2606; dermatologyresearch@cw.bc.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 21, 2025
• First Posted: December 8, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: December 8, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)