Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction

NCT07268235 | Completed

• 1 other identifier: Micro-TESE
• Study Type: observational
• Target: 129
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.

Conditions

Microdissection Testicular Sperm Extraction

Keywords

Nonobstructive Azoospermia; oligoasthenoteratozoospermia; intracytoplasmic sperm injection; In vitro fertilization; cryptozoospermia

Outcome Measures

Primary Outcomes (1)

• Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval

  For IVF performed from June 2015 to January 2025

Secondary Outcomes (3)

• Percentage of fertilized oocytes with two pronuclei (2PN)

  For IVF performed from June 2015 to January 2025

• Percentage of usable blastocyst (defined as frozen and transferred blastocysts)

  For IVF performed from June 2015 to January 2025

• Pregnancy rate based on positive β-hCG

  For IVF performed from June 2015 to January 2025

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Men who underwent a micro-TESE for IVF treatment

You may qualify if:

• Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025.
• Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses)
• Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation)
• Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology)

You may not qualify if:

• Patients who did not have any sperm noted following micro-TESE
• Use of donor sperm or oocytes
• Frozen sperm or oocytes
• Same day oocyte retrieval and sperm extraction
• Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)

Sponsors & Collaborators

• Clinique Ovo: lead

Study Sites (1)

Clinique ovo

Montreal, Quebec, H4P 2S4, Canada

Location

MeSH Terms

Conditions

Azoospermia, Nonobstructive; Oligospermia

Condition Hierarchy (Ancestors)

Infertility, Male; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Infertility; Male Urogenital Diseases

Study Officials

• Isaac-Jacques Kadoch, MD

  Clinique Ovo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: December 5, 2025
• Study Start: November 15, 2025
• Primary Completion: November 30, 2025
• Study Completion: November 30, 2025
• Last Updated: December 5, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)