Effectiveness of Oral Iron Therapy in Iron Deficiency Anemia With Daily vs Alternate Day Dosing

NCT07267975 | Completed Phase 3 DMC

• 1 other identifier: No/1032/CH-UCHS
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Treating iron deficiency anemia in children with daily and alternate day oral iron therapy

Conditions

Iron Deficiency Anemia; Iron Deficiency Anemia Treatment

Keywords

IDA, children, oral iron

Outcome Measures

Primary Outcomes (2)

• Rise in hemoglobin level after oral iron

  Hemoglobin level change in g/dl

  3 months

• Change in Hemoglobin level

  Hb rise in g/dl

  3month

Secondary Outcomes (1)

• Rise in ferritin level

  3 month

Study Arms (2)

Continuous oral iron therapy

ACTIVE COMPARATOR

Oral iron daily dosing 6mg/kg/day

Drug: Ferrous sulphate

Intermittent oral iron

EXPERIMENTAL

Oral iron therapy on alternate day with dose of 6mg /kg/day for 3 mons

Drug: Ferrous sulphate

Interventions

Ferrous sulphate DRUG

Continuous vs intermittent oral iron therapy to see the difference of Hemoglobin rose in both group

Also known as: Daily dosing

Continuous oral iron therapy

Eligibility Criteria

• Age: 1 Day - 5 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• \- Patients of both genders with ages in the range of 0 -60 months suffering from IDA as per operational definition.

You may not qualify if:

• Who have already taken treatment for IDA during last 2-months as per history/clinical record.
• Who have undergone recent blood transfusion during last 12-weeks as per history/clinical record.
• Children with chronic kidney disease, chronic liver disease, cardiac failure or concomitant malignancy

Sponsors & Collaborators

• University of Child Health Sciences and Children's Hospital, Lahore: lead

Study Sites (1)

University of child health science and the children hospital lahore

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Anemia, Iron-Deficiency

Interventions

ferrous sulfate

Condition Hierarchy (Ancestors)

Anemia, Hypochromic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Iron Deficiencies; Iron Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PGR

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: December 5, 2025
• Study Start: January 7, 2025
• Primary Completion: March 7, 2025
• Study Completion: May 7, 2025
• Last Updated: December 5, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)