Predictive Factors for Return to Work After a First Stroke Treated at Clermont-Ferrand University Hospital in Puy de Dôme Between January 2020 and December 2024

NCT07264387 | Recruiting

• 1 other identifier: RNI 2025 ORANGE
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 2

Brief Summary

Stroke is a leading cause of acquired motor disability and the second most common cause of major cognitive impairment worldwide. In France, approximately 150,000 new cases occur annually, with around 31% affecting individuals of working age, making return to work (RTW) a critical public health issue. Beyond the medical burden, stroke has profound socio-economic consequences, including loss of productivity, prolonged sick leave, part-time resumption, and the need for workplace adaptations. While RTW after stroke has been investigated, major gaps remain. No standardized recommendations exist for vocational reintegration, and predictive factors are still debated. Quantitative determinants such as stroke type, severity, functional independence, and occupational characteristics have been identified, but qualitative aspects-including self-efficacy, perceived social burden, employer relationships, and motivation-are poorly documented. Moreover, cognitive deficits are often insufficiently characterized, as screening tools such as MMSE or MoCA lack the sensitivity of comprehensive neuropsychological assessments. The impact of revascularization procedures on RTW and the ability to sustain employment after initial resumption also remain unclear. Importantly, no recent data are available in the Auvergne region, despite evolving labor policies that may influence reintegration trajectories. This observational study therefore aims to identify both quantitative and qualitative predictors of RTW after ischemic or hemorrhagic stroke, describe vocational pathways in a regional cohort, and explore barriers and facilitators to long-term reintegration. Ultimately, the study seeks to provide updated evidence to guide tailored rehabilitation and socio-professional reintegration strategies, supporting sustainable RTW in working-age stroke survivors.

Conditions

Stroke

Keywords

stroke; return to work; predictive factors

Outcome Measures

Primary Outcomes (6)

• Return to work rate

  Percentage of return to work after a first ischaemic or haemorrhagic stroke between January 2020 and December 2024 in patients of working age.

  At inclusion

• Factors correlated with return to work

  Determine the factors associated with return to work (gender)

  At inclusion

• Factors correlated with return to work

  Determine the factors associated with return to work (stroke severity)

  At inclusion

• Factors correlated with return to work

  Determine the factors associated with return to work (stroke type (ischaemic or haemorrhagic)).

  At inclusion

• Factors correlated with return to work

  Determine the factors associated with return to work (independence)

  At inclusion

• Factors correlated with return to work

  Determine the factors associated with return to work (occupation)

  At inclusion

Secondary Outcomes (5)

• Quality of life after stroke

  At inclusion

• Anxiety and Depression scale

  At inclusion

• Fatigue Severity Scale

  At inclusion

• Predictive score for return-to-work rate

  At inclusion

• Job retention

  At inclusion

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Stroke management follows a continuum, starting with acute care in neurology and neurosurgery, then progressing to medium- and long-term multidisciplinary rehabilitation in the Physical Medicine and Rehabilitation (PMR) department of Clermont-Ferrand University Hospital. Within this context, return to work is a key objective, supported by the expertise of PMR teams and close collaboration with neurology and neurosurgery. To conduct this study, authorisation to access medical records was granted by the Medical Information Department (DIM), covering patients under 64 years old admitted for ischaemic or haemorrhagic stroke between January 2020 and December 2024. Screening will be performed on hospitalisations in neurology and neurosurgery, and all eligible patients experiencing a first stroke during this period will be invited to participate.

You may qualify if:

• Patients who have suffered an ischaemic stroke according to ICD-10 (ICD-10 code: I63 (cerebral infarction) I64 (unspecified stroke), I69 (sequelae of cerebrovascular disease) or patients who have had a haemorrhagic stroke according to ICD-10 (ICD-10 code: I60, I61 and I62) between January 2020 and March 2024
• Patients of working age/under 64 years of age (legal retirement age)
• Patients with an employment contract at the time of the stroke
• Patients treated at Clermont-Ferrand University Hospital
• Post-stroke consultation recorded in the patient's medical file
• Patients affiliated with the social security system
• Patients who have not objected to participating in the study

You may not qualify if:

• Patients with a history of ischaemic or haemorrhagic stroke
• Patients with a history of head trauma with neurological sequelae corresponding to codes S060, S061, S062, S063, S065, S066, S067, S068 and S069
• Patients who died as a result of stroke
• Patients unable to respond to telephone questionnaires
• Patients under guardianship or trusteeship
• Patients who have suffered a transient ischaemic attack (TIA) (G459 according to ICD 10)
• Patients who were in early retirement at the time of assessment
• No information on employment after stroke in the medical file
• Patients with category 2 or 3 disability prior to stroke due to another condition
• Patients on sick leave prior to stroke due to another condition
• Patients receiving RSA income support

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (2)

Clermont Ferrand University Hospital, Louise Michel site

Cébazat, France, 63118, France

RECRUITING

CHU Clermont-Ferrand, Louise Michel

Clermont-Ferrand, France

NOT YET RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Lise Laclautre

  University Hospital, Clermont-Ferrand

  STUDY DIRECTOR

Central Study Contacts

Lise Laclautre

CONTACT

+33473754963; promo_interne_drci@chu-clermontferrand.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2025
• First Posted: December 4, 2025
• Study Start: October 29, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: December 4, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)