Effects of Lower Extremity Neuromuscular Facilitation and Patients With Multiple Sclerosis

NCT07263854 | Completed

• 1 other identifier: hakanpolat7
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 2

Brief Summary

Objective: This study aimed to investigate the effects of lower extremity Proprioceptive Neuromuscular Facilitation (PNF) exercises on balance, gait, and fatigue in patients with Multiple Sclerosis (MS). Method: Twenty-six MS patients (18 women, 8 men) were included in the study. Participants were divided into two groups. The study group (n=13) underwent lower extremity Proprioceptive Neuromuscular Facilitation exercises, while the control group (n=13) underwent lower extremity strengthening exercise training three days a week for six weeks. Static balance, tandem stance test, dynamic balance, walking with the 4-step square test, walking with the 25-step test, and fatigue were assessed twice, before and after treatment, using the fatigue severity scale.

Conditions

Gait Balance; Balance; Fatigue Syndrome, Chronic

Keywords

multipl skleroz; balance; gait; fatigue

Outcome Measures

Primary Outcomes (4)

• static balance

  tandem stance test

  6 weeks

• dynamic balance

  four-square test

  6 weeks

• gait

  25-step walking test

  6 weeks

• fatigue

  Fatigue Severity Scale (fSS): The \*\*Fatigue Severity Scale (FSS)\*\* is a 9-item measure that assesses the severity of fatigue, with each item scored on a scale of 1-7. The average score on the scale is typically considered. \*\*A low FSS score (1.0-3.9)\*\* indicates mild fatigue that does not significantly affect daily life; the individual generally has normal energy levels, and fatigue does not restrict work or social life. A \*\*high FSS score (4.0-7.0)\*\* indicates that fatigue is markedly excessive and negatively affects daily activities; it is consistent with decreased energy, difficulty performing activities, and fatigue seen in chronic illnesses. Clinically, an average score of \*\*4 or above\*\* is considered \*\*significant fatigue\*\*, while a score below 4 is considered \*\*low fatigue\*\*.

  6 weeks

Study Arms (2)

working group

EXPERIMENTAL

Proprioceptive neuromuscular facilitation (PNF) exercises

Other: exercises

control group

EXPERIMENTAL

strengthening exercises

Other: exercises

Interventions

exercises OTHER

Each of the two groups was given exercise three days a week for six weeks.

control group; working group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• (i) Having been diagnosed with Relapsing-Remitting Multiple Sclerosis (RRMS) according to the 2017 McDonald criteria (Thompson, Banwell et al. 2018), (ii) Aged 18-65 years, (iii) Expanded Disability Status Scale (EDSS) score of 4 or below, (iv) No relapses in the past 6 months.

You may not qualify if:

• (i) Having a history of trauma to the lower extremities within the last year, (ii) having a known history of other chronic neurological disorders, (iii) having any contraindications to exercise, (iv) cognitive impairment as defined by a mini-mental test (scoring below 24 points).

Sponsors & Collaborators

• Sanko University: lead

Study Sites (2)

Sanko Unıversıty

Gaziantep, Gaziantep, 27090, Turkey (Türkiye)

Location

Sanko Unıversıty

Gaziantep, Gaziantep, 27500, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Fatigue Syndrome, Chronic; Fatigue

Interventions

Exercise

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Encephalomyelitis; Neuroinflammatory Diseases; Nervous System Diseases; Neuromuscular Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: dırector

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: December 4, 2025
• Study Start: July 1, 2025
• Primary Completion: August 1, 2025
• Study Completion: September 16, 2025
• Last Updated: December 4, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (2)