NCT07260084

Brief Summary

The goal of this observational study is to show prognostic impact of frailty in cardiogenic shock according to age. The main questions it aims to answer are:

  • Can frailty successfully predict outcomes in cardiogenic shock?
  • Whether the impact of frailty would differ with age in cardiogenic shock?

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
207,419

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2012

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
11.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2023

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

September 24, 2025

Completed
2 months until next milestone

First Posted

Study publicly available on registry

December 3, 2025

Completed
Last Updated

December 3, 2025

Status Verified

November 1, 2025

Enrollment Period

11.8 years

First QC Date

September 24, 2025

Last Update Submit

November 21, 2025

Conditions

Cardiogenic ShockFrailtyAge

Keywords

frailtycardiogenic shockHospital Frailty Risk ScoreAge

Outcome Measures

Primary Outcomes (1)

  • In-hospital all-cause mortality

    Death from any cause occurring during the index hospitalization for cardiogenic shock. Number of participants with the event was measured

    During index hospitalization for cardiogenic shock (up to hospital discharge)

Secondary Outcomes (4)

  • Heart failure-related rehospitalization

    From index hospitalization until 15 years of follow-up.

  • Cognitive impairment

    From index hospitalization until 15 years of follow-up.

  • Mental health problems

    From index hospitalization until 15 years of follow-up.

  • Long-term all-cause mortality

    From index hospitalization until 15 years of follow-up.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults aged ≥18 years who were admitted to the intensive care unit (ICU) of tertiary hospitals and were diagnosed with CS

You may qualify if:

  • Adults aged ≥18 years who were admitted to the intensive care unit (ICU) of tertiary hospitals and were diagnosed with CS

You may not qualify if:

  • Patients diagnosed with anaphylaxis
  • Patients with a documented history of shock in the year before the index admission

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Shock, CardiogenicFrailty

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisShock

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 24, 2025

First Posted

December 3, 2025

Study Start

January 1, 2012

Primary Completion

October 31, 2023

Study Completion

October 31, 2023

Last Updated

December 3, 2025

Record last verified: 2025-11