Postoperative Analgesia Practices After Percutaneous Nephrolithotomy

NCT07258901 | Not Yet Recruiting

• 1 other identifier: 231-2025
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the effectiveness and safety of different postoperative analgesia methods used in patients undergoing percutaneous nephrolithotomy (PCNL). Analgesia techniques are determined independently by the responsible anesthesiologist as part of routine clinical practice, and the study team does not intervene in treatment decisions.

Conditions

Nephrolithiasis

Keywords

Percutaneous Nephrolithotomy; Postoperative Analgesia; Pain Management; Regional Anesthesia; Nephrolithiasis

Outcome Measures

Primary Outcomes (1)

• Cumulative opioid consumption

  Cumulative opioid consumption in the first 24 hours

  24 hours

Secondary Outcomes (6)

• Pain scores at rest and during movement

  0, 2, 6, 12, and 24 hours postoperatively

• Time to first analgesic request

  Postoperative 24 hours

• Need for rescue analgesics

  24 hours

• Intraoperative opioid consumption

  During surgery

• Antiemetic medication use

  24 hours

Study Arms (3)

quadro iliac plane block

quadro iliac plane block

erector spinae nerve block

erector spinae nerve block

Intravenous opioid-based analgesia

Intravenous opioid-based analgesia

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18 to 65 years undergoing unilateral percutaneous nephrolithotomy (PCNL) at Haseki Training and Research Hospital. All participants are ASA physical status I-III and receive postoperative analgesia according to routine clinical practice.

You may qualify if:

• Adults aged 18-65 years
• ASA physical status I-III
• Undergoing unilateral PCNL
• Providing written informed consent

You may not qualify if:

• Known allergy to local anesthetics
• Coagulopathy or contraindication to regional anesthesia
• BMI \> 35 kg/m²
• Cognitive or communication impairment affecting pain evaluation
• Neurological or psychiatric disorders
• Musculoskeletal abnormalities
• Chronic opioid use, alcohol or substance abuse history
• Previous PCNL or open renal surgery on the same side
• Refusal to participate

Sponsors & Collaborators

• Istinye University: lead

Study Sites (1)

Haseki Training and Research Hospital

Istanbul, Sultangazi, 34265, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Nephrolithiasis; Agnosia

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Male Urogenital Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assoc prof

Study Record Dates

• First Submitted: November 20, 2025
• First Posted: December 2, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 2, 2026
• Last Updated: December 2, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)