RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

NCT07258784 | Recruiting

• 1 other identifier: HP-00114191
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Conditions

Tracheal Stenosis; Subglottic Stenosis

Outcome Measures

Primary Outcomes (1)

• RNA profile

  The diseased mucosa will show a increased fibrosis and inflammation profile compared with that from normal mucosa

  1 year

Study Arms (1)

patients with benign tracheal stenosis undergoing either endoscopic or surgical treatment

Procedure: Biopsy or surgery

Interventions

Biopsy or surgery PROCEDURE

The tissue will be obtained from biopsy or surgical resection. All the "intervention" will be performed for clinical needs. The tissue used in the study will be considered as discarded tissue

patients with benign tracheal stenosis undergoing either endoscopic or surgical treatment

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with benign tracheal stenosis, including idiopathic, iatrogenic, autoimmune.

You may qualify if:

• Patients with benign tracheal stenosis

You may not qualify if:

• Malignancy. active infection

Sponsors & Collaborators

• University of Maryland, Baltimore: lead

Study Sites (1)

University of Maryland

Baltimore, Maryland, 21201, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Biopsied or resected stenotic tissue from patients with benign tracheal stenosis

MeSH Terms

Conditions

Tracheal Stenosis

Interventions

Biopsy; Surgical Procedures, Operative

Condition Hierarchy (Ancestors)

Tracheal Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Specimen Handling; Diagnostic Techniques, Surgical; Investigative Techniques

Central Study Contacts

Chenchen Zhang, MD

CONTACT

14103288141; chenchen.zhang@som.umaryland.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: November 20, 2025
• First Posted: December 2, 2025
• Study Start: September 11, 2025
• Primary Completion (Estimated): September 10, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: December 2, 2025

Record last verified: 2025-09

Locations

US (1)