NCT07254078

Brief Summary

The goal of this observational study is to gather information on background, medical history, symptoms and physical condition, treatment options of people with chronic thromboembolic pulmonary hypertension in real clinical practice in Russia. The main question it aims to answer is: Which factors most influence the prognosis of participants?

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
110mo left

Started May 2025

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress10%
May 2025May 2035

Study Start

First participant enrolled

May 1, 2025

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

November 19, 2025

Completed
9 days until next milestone

First Posted

Study publicly available on registry

November 28, 2025

Completed
9.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2035

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2035

Last Updated

December 12, 2025

Status Verified

December 1, 2025

Enrollment Period

10 years

First QC Date

November 19, 2025

Last Update Submit

December 4, 2025

Conditions

Chronic Thromboembolic Pulmonary Hypertension

Keywords

CTEPHregistryPEABPAPAH-specific therapysurvival

Outcome Measures

Primary Outcomes (1)

  • All-cause mortality

    Up to 5 years

Secondary Outcomes (3)

  • All-cause mortality

    Up to 10 years

  • Change in distance in 6-minute walk test

    1 year

  • Change in mPAP

    1 year

Interventions

Pulmonary endarterectomyPROCEDURE

A surgical procedure to remove chronic blood clots from the pulmonary arteries

Also known as: PEA, PTE, Pulmonary thromboendarterectomy
Balloon pulmonary angioplastyPROCEDURE

A minimally invasive procedure used to treat chronic thromboembolic pulmonary hypertension by dilatating narrowed pulmonary arteries and improving blood flow to the lungs

Also known as: BPA
Pulmonary hypertension-specific therapyDRUG

Medical treatment with any PH-specific drugs

Also known as: PH-specific therapy, PH-Targeted Medical Therapy

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

operable CTEPH, non-operable CTEPH

You may qualify if:

  • Presence of a confirmed diagnosis of CTEPH

You may not qualify if:

  • Presence of pulmonary hypertension of a different etiology than CTEPH

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Medical Research Center of Cardiology after academician E.I. Chazov

Moscow, Russia

RECRUITING

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Target Duration
10 Years
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR INVESTIGATOR
PI Title
D. Sci. (Med.), Acad. RAS, Prof., Deputy Director General for Scientific and Expert Work, FSBI NATIONAL MEDICAL RESEARCH CENTRE OF CARDIOLOGY NAMED AFTER ACADEMICIAN E.I.CHAZOV of the Ministry of Health of the Russian Federation

Study Record Dates

First Submitted

November 19, 2025

First Posted

November 28, 2025

Study Start

May 1, 2025

Primary Completion (Estimated)

May 1, 2035

Study Completion (Estimated)

May 1, 2035

Last Updated

December 12, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations

RU(1)