Load Dependent Modulation of Spinal Excitability: Linking H-Reflex Supression and Whole Body Vibration Induced Reflex Latency

NCT07253467 | Completed

• 1 other identifier: IstPRMTRH2A
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This study examines how different standing postures and whole-body vibration conditions affect spinal reflex activity. Participants will stand in various positions-with and without vibration of two amplitudes-and H-reflex responses from the soleus muscle will be recorded. Additionally, vibration-induced reflex latency will be assessed across multiple vibration frequencies.

Conditions

Vibration; H-reflex

Keywords

H-Reflex; Whole Body Vibration; Bone Myoregulation Reflex; Reflex Latency

Outcome Measures

Primary Outcomes (2)

• Whole Body Vibration induced reflex latency

  WBV induced reflex latency will be measured

  Day 1 (single-session, during each experimental condition)

• H-Reflex Size

  Peak to peak amplitude of the H-Reflex will be measured

  Day 1 (single-session, during each experimental condition)

Study Arms (1)

Healthy participants

EXPERIMENTAL

Participants will complete a series of experimental tasks involving postural mechanical and vibrational loading. The protocol consists of quiet standing on both feet, single-leg standing on the left side, standing during whole-body vibration (WBV), and single-leg standing on the left side during WBV. Vibration amplitudes of 2.2 mm and 1.2 mm will be applied in each condition. H-reflex measurements will be recorded from the soleus muscle throughout all tasks to evaluate alterations in spinal reflex excitability. Vibration induced reflex latency will be also measured with different vibration frequencies (30-32-34-36) also measured in the same protocol.

Other: Whole Body Vibration

Interventions

Whole Body Vibration OTHER

Whole Body Vibration (WBV) is a neuromuscular training modality in which patients stand, sit, or exercise on a platform that delivers mechanical oscillations (30-36 Hz, 1-2 mm amplitude). While WBV is applied H-Reflex tests are done.

Healthy participants

Eligibility Criteria

• Age: 25 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults between 25 and 50 years of age
• Individuals willing to participate and able to provide informed consent
• Individuals who can stand independently for at least 10 minutes
• Participants with no known neurological, orthopedic, or balance impairments

You may not qualify if:

• Individuals who can not tolerate WBV
• Individuals who can not tolerate electrical stimulation
• Pregnancy

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Istanbul, Bahçelievler, 34158, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 19, 2025
• First Posted: November 28, 2025
• Study Start: November 21, 2025
• Primary Completion: December 8, 2025
• Study Completion: December 30, 2025
• Last Updated: March 25, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)