The Effect of Gender-affirmative Measures on Breast Perception in Trans Men

NCT07252687 | Recruiting

• 1 other identifier: 1125/2025
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Breast dysphoria in transmasculine or genderdiverse individuals is a distinct psychological burden associated with depression, anxiety and suicidality. The aim is to systematically investigate the effect of GAHT (gender-affirming hormone therapy) and mastectomy on this form of dysphoria. The primary objective of this study is to analyse and investigate the psychological and physical effects of breast development on trans men or genderdiverse individuals. A secondary objective is to determine the extent to which the stress affects the well-being of trans men depending on the coping strategies used (binding vs. taping).

Conditions

Transgender; Gender Dysphoria in Adolescents and Adults

Keywords

transgender; breastdysphoria; trans male; non binary; genderdiverse

Outcome Measures

Primary Outcomes (1)

• Chest Dysphoria Measure Score

  Chest Dysphoria Measure Score before GAHT, during GAHT, and after mastectomy. Possible chest dysphoria scores range from 0 to 51, with higher scores indicating greater distress.

  From enrollment to the end of observation after 2 years

Interventions

quality of life questionnaire- iTransQoL, chest dysphoria measure OTHER

Before starting treatment, participants should complete the Chest Dysphoria Measure and iTransQoL questionnaires (=time point 0). The second time point for completing the questionnaires again is 3 months after starting hormone therapy. Subsequently, the questionnaires should be completed a third time after breast-affirming surgery. The final survey takes place two years after time point 0, or 6 months after the previous survey.

Eligibility Criteria

• Age: 16 Years+
• Gender Eligibility Details: trans men and gender diverse persons
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Referral to the medical University of Innsbruck Hospital or a cooperating center

You may qualify if:

• AFAB (Assigned Female At Birth)
• before starting GAHT
• before mastectomy

You may not qualify if:

• Ongoing GAHT
• Mastectomy already performed
• Lack of capacity to give consent
• Insufficient knowledge of German

Sponsors & Collaborators

• Medical University Innsbruck: lead

Study Sites (1)

Medical University Innsbruck

Innsbruck, Austria

RECRUITING

Central Study Contacts

Katharina Feil

CONTACT

+4351250423276; katharina.feil@i-med.ac.at

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 28, 2025
• Study Start: November 30, 2025
• Primary Completion (Estimated): November 1, 2030
• Study Completion (Estimated): November 1, 2030
• Last Updated: March 6, 2026

Record last verified: 2025-11

Locations

AU (1)