Serum Chordecone Concentration in Guadeloupean Population: Impact of a Multidisciplinary Support Program on the Reduction of the Contamination Level.

NCT07251036 | Recruiting

• 1 other identifier: PAP_RIPH2_2022/01
• Study Type: interventional
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

The French West Indies (Guadeloupe, Martinique) are characterized by a major use of pesticides in bananas plantation from the 1950s. These crops used organochlorine insecticides and especially chlordecone (CLD) from 1972 to 1993. The lack of biotic and abiotic degradation of CLD led to persistent soil pollution, contamination of surface and deep waters, of numerous plant and animal, and of the population. The extent and persistence of CLD contamination over time is a major issue for these territories. An internal reference value (0.4μg/l) was recently determined. Although useful for a population approach, it must be used with caution for the interpretation of an individual result. In response to the strong social demand expressed by the population for access to free chlordecone blood tests, a screening program for blood chlordecone test was authorized by the 2019 French Finance Act.

Conditions

Chlordecone Level

Keywords

risk factors; pesticides; Guadeloupe; chlordecone

Outcome Measures

Primary Outcomes (2)

• chlordecone level

  ug/l

  between Day0 to Day15

• risk factors

  chlordeconemia survey

  between day 15 and day 45 ,

Secondary Outcomes (4)

• chlordecone level

  At 9 months after intervention

• chlordecone level

  At 18 months after intervention

• chlordecone level

  at delivery for pregnant women

• impact of an intervention

  between day 15 to day 45, at month 9 and month 18

Study Arms (1)

guadeloupean subject

OTHER

All subject overs 18 years of age residing in Guadeloupe invited to participate to the program

Other: CHLORGUA

Interventions

CHLORGUA OTHER

The target populations will receive an invitation letter with an information notice and a consent form. The referral physician will explain the program and the research project and prescribe a standardized blood sample test. Blood samples will be taken in one of the biology laboratories participating in the project. Serum chordecone test will be performed by the Pasteur Institute of Guadeloupe. Blood samples for biological collection will be sent to the Biological Resource Center, Karubiotec™. The result of the chlordécone level will be sent back to each subject with a recommendation note based on the chlordécone level value. Phone contact information for

guadeloupean subject

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Refusal to participate
• Person not affiliated with a social security scheme
• Person under legal protection (safeguard of justice, guardianship, curatorship, etc.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead

Study Sites (1)

Centre Hospitalier Universitaire de la Guadeloupe

Pointe-à-Pitre, Guadeloupe, 97159, Guadeloupe

RECRUITING

Study Officials

• Jacqueline DELOUMEAUX, Doctor

  CHU de la Guadeloupe

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Valérie HAMONY-SOTER

CONTACT

+590590934686; valerie.soter@chu-guadeloupe.fr

Eunice NUBRET

CONTACT

eunice.nubret@chu-guadeloupe.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 26, 2025
• Study Start: June 26, 2022
• Primary Completion (Estimated): June 1, 2028
• Study Completion (Estimated): June 1, 2028
• Last Updated: November 26, 2025

Record last verified: 2025-10

Locations

GU (1)