Fluid Responsiveness With Passive Leg Raising in Patients Undergoing Coronary Artery Bypass Surgery

NCT07245485 | Completed

• 1 other identifier: TABED 1-25-1556
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the reliability of corrected carotid flow time (ccFT) and the percentage change in peak flow velocity (ΔVpeak), as non-invasive methods for assessing fluid responsiveness using the passive leg raising (PLR) test in patients undergoing coronary bypass surgery.

Conditions

Passive Leg Raising; Corrected Carotid Flow Time; Fluid Responsiveness

Keywords

Hemodynamic Monitoring; Corrected Carotid Flow Time; Passive Leg Raising

Outcome Measures

Primary Outcomes (4)

• hemodynamic parameters (T0)

  After patient monitoring, hemodynamic parameter values will be recorded before anesthesia induction

  before anesthesia induction

• hemodynamic parameters (T1)

  Hemodynamic parameters will be recorded after anesthesia induction.

  after anesthesia induction

• ccFT and Hemodynamic parameters (T3)

  After the patient is placed in a 45-degree head-up position, ccFT will be measured and hemodynamic parameters will be recorded.

  After the patient is placed in a 45-degree head-up position

• ccFT and Hemodynamic Parameters (T4)

  After passive leg raising, ccFT and hemodynamic parameters will be recorded.

  After passive leg raising

Secondary Outcomes (2)

• Delta Vpeak

  After the patient is placed in a 45-degree head-up position

• Delta Vpeak

  After passive leg raising

Study Arms (1)

Study Group

After the patient is placed in a 45-degree head-up position, ccFT will be measured and hemodynamic parameters will be recorded.After passive leg raising, ccFT and hemodynamic parameters will be recorded.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 50 patients undergoing elective coronary artery bypass surgery under general anesthesia in the Cardiovascular Surgery operating room

You may qualify if:

• A total of 50 patients undergoing elective coronary artery bypass surgery under general anesthesia in the Cardiovascular Surgery operating room of the Ministry of Health Ankara Bilkent City Hospital will be included in the study.
• The volunteers to be included will be patients aged between 18 and 80 years, evaluated as ASA class II-III according to the American Society of Anesthesiologists (ASA) classification.

You may not qualify if:

• Patients who do not wish to participate in the study
• Patients younger than 18 or older than 80 years
• Patients with an ASA score greater than III
• Patients with BMI \> 35
• Patients with EF \< 40%
• Patients with atrial fibrillation
• Patients with severe valvular stenosis or insufficiency
• Patients with right ventricular dysfunction
• Patients with carotid artery stenosis
• Patients with a history of cerebrovascular accident or transient ischemic attack
• Patients with increased intra-abdominal or intracranial pressure
• Patients with glaucoma
• Patients with severe renal or hepatic disease
• Patients who develop hemodynamic instability during the perioperative period
• Pregnancy

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation, Ankara, Çankaya

Ankara, Çankaya, 06800, Turkey (Türkiye)

Location

Related Publications (4)

• Singla D, Gupta B, Varshney P, Mangla M, Walikar BN, Jamir T. Role of carotid corrected flow time and peak velocity variation in predicting fluid responsiveness: a systematic review and meta-analysis. Korean J Anesthesiol. 2023 Jun;76(3):183-193. doi: 10.4097/kja.22385. Epub 2022 Nov 15.

  PMID: 36377330 BACKGROUND

• Walker SCD, Lipszyc AC, Kilmurray M, Wilding H, Akhlaghi H. Questioning the Role of Carotid Artery Ultrasound in Assessing Fluid Responsiveness in Critical Illness: A Systematic Review and Meta-Analysis. Crit Care Res Pract. 2024 Apr 27;2024:9102961. doi: 10.1155/2024/9102961. eCollection 2024.

  PMID: 38716052 BACKGROUND

• Cheong I, Otero Castro V, Sosa FA, Tort Oribe B, Fruchtenicht MF, Tamagnone FM, Merlo PM. Passive leg raising test using the carotid flow velocity-time integral to predict fluid responsiveness. J Ultrasound. 2024 Mar;27(1):97-104. doi: 10.1007/s40477-023-00824-1. Epub 2023 Sep 5.

  PMID: 37668901 BACKGROUND

• Suresh V, Sethuraman M, Karunakaran J, Koshy T. Fluid responsiveness to passive leg raising in patients with and without coronary artery disease: A prospective observational study. Ann Card Anaesth. 2020 Oct-Dec;23(4):439-446. doi: 10.4103/aca.ACA_73_19.

  PMID: 33109801 BACKGROUND

Study Officials

• Ümit Karadeniz, Professor

  Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation, Ankara, Çankaya

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 24, 2025
• First Posted: November 24, 2025
• Study Start: December 30, 2025
• Primary Completion: January 21, 2026
• Study Completion: February 14, 2026
• Last Updated: February 20, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)