NCT07245199

Brief Summary

The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
8mo left

Started Jan 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress35%
Jan 2026Jan 2027

First Submitted

Initial submission to the registry

October 2, 2025

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 24, 2025

Completed
1 month until next milestone

Study Start

First participant enrolled

January 1, 2026

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

November 24, 2025

Status Verified

September 1, 2025

Enrollment Period

1 year

First QC Date

October 2, 2025

Last Update Submit

November 20, 2025

Conditions

No Condition, Healthy Individuals

Outcome Measures

Primary Outcomes (1)

  • fractional synthetic rate

    24 hours

Study Arms (3)

BALANCED

EXPERIMENTAL
Dietary Supplement: protein intake

SIP

EXPERIMENTAL
Dietary Supplement: Protein intake

BOLUS

EXPERIMENTAL
Dietary Supplement: protein intake

Interventions

Protein intakeDIETARY_SUPPLEMENT

1x 100g

BOLUS

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Aged between 18-40 years
  • Healthy
  • ≤ BMI 30 ≤ kg・m-2

You may not qualify if:

  • Smoking
  • Sports/exercise \>4 sessions/week or a structured resistance or endurance training schedule
  • Lactose intolerant or allergies to milk protein
  • A history of neuromuscular problems
  • Use of anticoagulation medication
  • Individuals on any medications known to affect protein metabolism (i.e. , non-steroidal anti-inflammatories, or prescription acne medications).
  • Strict vegetarian
  • Injury or condition that would limit the participant from performing the resistance exercise.
  • Pregnancy
  • Hormone replacement therapy
  • Blood donation within the past 2 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Maastricht University

Maastricht, Netherlands

Location

Related Publications (2)

  • Mamerow MM, Mettler JA, English KL, Casperson SL, Arentson-Lantz E, Sheffield-Moore M, Layman DK, Paddon-Jones D. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr. 2014 Jun;144(6):876-80. doi: 10.3945/jn.113.185280. Epub 2014 Jan 29.

    PMID: 24477298RESULT

  • Areta JL, Burke LM, Ross ML, Camera DM, West DW, Broad EM, Jeacocke NA, Moore DR, Stellingwerff T, Phillips SM, Hawley JA, Coffey VG. Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol. 2013 May 1;591(9):2319-31. doi: 10.1113/jphysiol.2012.244897. Epub 2013 Mar 4.

    PMID: 23459753RESULT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 2, 2025

First Posted

November 24, 2025

Study Start

January 1, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2027

Last Updated

November 24, 2025

Record last verified: 2025-09

Locations

NL(1)