Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly With Mild Cognitive Impairment

NCT07242495 | Recruiting

• 1 other identifier: FUI/CTR/2025/09
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

One of the key challenges faced by individuals with Mild Cognitive Impairment (MCI) is the decline in cognitive abilities, particularly global cognition, attention, and executive function, which are essential for maintaining independence and performing daily activities. Impaired cognition can significantly reduce quality of life in older adults, leading to difficulties in managing routine tasks, reduced social engagement, and increased dependency on caregivers. Common signs and symptoms include forgetfulness, difficulty concentrating, slower problem-solving, and challenges in planning or organizing daily activities. This study aims to explore and compare the effectiveness of two interventions-immersive Virtual Reality (VR) 360-degree videos combined with aerobic exercises, and aerobic exercises alone-in improving cognitive functions in older adults with MCI. Key outcome measures, including the Montreal Cognitive Assessment (MoCA) and Trail Making Test (TMT), will evaluate the effectiveness of the interventions on global cognition, attention, and executive function. We will include older adults aged 60 years and above with MoCA scores between 18-25 (MCI patients), who are able to perform independent ADLs. The participants will be assessed at the start of the intervention through the MoCA scale for MCI screening and baseline TMT testing for inclusion.

Conditions

Cognitive Dysfunctions; Cognitive Disorder; Cognitive Decline

Keywords

Cognitive rehabilitation; Virtual Reality; Mild cognitive Impairment; Elderly; Aerobic exercise

Outcome Measures

Primary Outcomes (2)

• Cognitive function

  Montreal Cognitive Assessment (MoCA) will be used for this. Values: 26-30 = Normal cognition 18-25 = Mild Cognitive Impairment (MCI) 10-17 = Moderate cognitive impairment \<10 = Severe cognitive impairment

  6 weeks

• Attention

  Trail Making Test will be used for this. Values: TMT-A: \<40 seconds = Above average 40-60 seconds = Average TMT-B: \<75 seconds = Above average 75-180 seconds = Average

  6 weeks

Study Arms (2)

VR 360 degree Videos and Aerobic Chair Exercises intervention

EXPERIMENTAL

Intervention: Combination of immersive VR 360° videos and structured chair-based aerobic exercises Session Duration: Starts at 15 minutes, progresses up to 25 minutes Frequency: 2 sessions per week Total Duration: 6 weeks VR Content: Forest, wildlife, space, wildlife, solar system, waterfalls, room environments Aerobic Exercises: Chair-based aerobic exercises (upper and lower limb movements, rhythmic seated marching, arm raises) Additional Task: Short memory recall activity to explain the main events, details and characters in the VR 360 degree video at the end of each VR session

Procedure: VR 360 degree Videos and Aerobic Chair Exercises intervention

Chair Aerobic Exercises

ACTIVE COMPARATOR

Chair aerobic exercises 15 min/day with progression upto 25 min, 2 days a week, for 6 weeks. Chair aerobic exercise includes: 1. Alternate heel digs with bilateral biceps curl 8 repetitions per session. 2. V- Step with bilateral hammer curls 8 repetitions per session. 3. Lateral step touch with bilateral biceps curls 8 repetitions per session. 4. Knee lift 8 repetitions per session. 5. Arm swings 8 repetitions per session. 6. Clap swing 8 repetitions per session. 7. Sit, stand and clap 8 repetitions per session

Procedure: Chair Aerobic Exercises

Interventions

VR 360 degree Videos and Aerobic Chair Exercises intervention PROCEDURE

Combination of immersive VR 360° videos and structured chair-based aerobic exercises Session Duration: Starts at 15 minutes, progresses up to 25 minutes Frequency: 2 sessions per week Total Duration: 6 weeks VR Content: Forest, wildlife, space, wildlife, solar system, waterfalls, room environments Aerobic Exercises: Chair-based aerobic exercises (upper and lower limb movements, arm raises) Additional Task: Short memory recall activity to explain the main events, details and characters in the VR 360 degree video at the end of each VR session.

VR 360 degree Videos and Aerobic Chair Exercises intervention

Chair Aerobic Exercises PROCEDURE

Chair aerobic exercises 15 min/day with progression upto 25 min, 2 days a week, for 6 weeks. Chair aerobic exercise includes: 1. Alternate heel digs with bilateral biceps curl 8 repetitions per session. 2. V- Step with bilateral hammer curls 8 repetitions per session. 3. Lateral step touch with bilateral biceps curls 8 repetitions per session. 4. Knee lift 8 repetitions per session. 5. Arm swings 8 repetitions per session. 6. Clap swing 8 repetitions per session. 7. Sit, stand and clap 8 repetitions per session

Chair Aerobic Exercises

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older population aged from 60years and above
• Normal/ normal to corrected vision
• MoCA Score of 18-25 for screening / MCI patients
• Can do Independent ADLS

You may not qualify if:

• Individuals with preexisting conditions such as severe motion sickness that could be exacerbated by VR usage.
• Communication impairments
• Participants with other neurological disorders.
• Sensory deficits (such as uncontrolled hearing or visual issues)

Sponsors & Collaborators

• Foundation University Islamabad: lead

Study Sites (1)

Foundation University College of Physical Therapy

Islamabad, 46000, Pakistan

RECRUITING

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Zara Amir, DPT

CONTACT

+92 3498273139; sp24npt011@fui.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 21, 2025
• Study Start: September 14, 2024
• Primary Completion: December 10, 2025
• Study Completion: January 10, 2026
• Last Updated: November 21, 2025

Record last verified: 2025-11

Locations

PA (1)