Efficacy of Different Types of Chemical Peels in the Treatment of Acne Vulgaris

NCT07240051 | Completed DMC

• 1 other identifier: MS-327-2023
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial.

Conditions

Acne; Peeling

Keywords

acne vulgaris; chemical peeling

Outcome Measures

Primary Outcomes (1)

• improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index

  6 months

Study Arms (3)

glycolic acid group

ACTIVE COMPARATOR

30 patients received 50% glycolic acid peels

Procedure: Glycolic acid peel alone

Salicylic acid group

ACTIVE COMPARATOR

30 patients received Salicylic acid 30%

Procedure: salicylic acid

Modified Jessener group

ACTIVE COMPARATOR

30 patients received MJ peel

Procedure: modified jessener

Interventions

Glycolic acid peel alone PROCEDURE

Using a cotton tip applicator, a single coat of commercially prepared 50% GA peeling agent was evenly applied to the patient's face. Neutralization of the peel was done on reaching uniform erythema (endpoint) within 3-5 minutes. If frosting was observed in any area before the set time or endpoint, the area was neutralized with sodium bicarbonate

glycolic acid group

salicylic acid PROCEDURE

Using a cotton tip applicator, a single coat of commercially prepared 30% SA peeling agent was evenly applied to the patient's face, moving from the forehead and advancing to the cheeks, chin, glabella, nose, and perioral area. Once white crystallization appeared, patients were asked to wash their faces with water.

Salicylic acid group

modified jessener PROCEDURE

Commercially prepared MJ peel was applied using a gauze piece and light hand pressure. A single coat of peel was uniformly applied over the entire face. The coat was allowed to dry completely until erythema or frosting occurred, at which point patients were asked to wash their faces with cold water.

Modified Jessener group

Eligibility Criteria

• Age: Up to 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Facial active acne (mild and moderate cases)
• post-acne hyperpigmentation
• a minimum age of 18 years
• skin phototype III or IV

You may not qualify if:

• Pregnant or nursing women
• active infection in the treatment area (e.g., verrucae and herpes simplex)
• systemic disease (hypertension, diabetes, or bleeding tendency)
• systemic retinoid or laser treatment within the last 6 months
• history of keloidal tendency or Aspirin sensitivity.

Sponsors & Collaborators

• Nahla Maher Mahmoud Mahran: lead

Study Sites (1)

Cairo University

Cairo, 13114, Egypt

Location

MeSH Terms

Conditions

Acne Vulgaris

Interventions

Salicylic Acid

Condition Hierarchy (Ancestors)

Acneiform Eruptions; Skin Diseases; Skin and Connective Tissue Diseases; Sebaceous Gland Diseases

Intervention Hierarchy (Ancestors)

Salicylates; Hydroxybenzoates; Benzoates; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Phenols

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: lecturer of Dermatology

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: November 20, 2025
• Study Start: March 9, 2024
• Primary Completion: June 10, 2024
• Study Completion: July 12, 2024
• Last Updated: November 20, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)