Vitamin D, Nerve Growth Factor and Nerve Conduction Studies in Adult Male Type 2 Diabetic Neuropathy Patients

NCT07236723 | Not Yet Recruiting

• 1 other identifier: diabetic neuropathy
• Study Type: observational
• Target: 57
• Locations: 1 country
• Sites: 2

Brief Summary

study the relationship of vitamin d with nerve growth factor level and nerve conduction studies in adult male type 2 diabetic neuropathy patients

Conditions

Diabetic Neuropathy

Keywords

vitamin d, nerve growth factor and diabetic neuropathy

Outcome Measures

Primary Outcomes (1)

• study the relation of vitamin d and nerve growth factor with nerve conduction studies in type 2 diabetic neuropathy male patients

  1. Difference in vitamin D level between diabetic neuropathy patients, diabetic patients without neuropathy and healthy subjects. 2. Difference in serum nerve growth factor level between diabetic neuropathy patients, diabetic patients without neuropathy and healthy subjects.

  one year

Study Arms (3)

control group

Group І: Control group included non-diabetic healthy males aged (40-60) years old

Other: 25(OH) vitamin D

type 2 diabetic male not suffering from diabetic neuropathy aged(40-60) years old

type 2 diabetic male not suffering from diabetic neuropathy aged(40-60) years old

Other: Nerve Growth Factor

type2 diabetic males suffering from diabetic neuropathy aged(40_60)years old

type2 diabetic males suffering from diabetic neuropathy aged(40\_60)years old

Other: nerve conduction studies

Interventions

nerve conduction studies OTHER

Assessment of neuropathy by nerve conduction studies of sural and tibial nerves in both lower extremities.

type2 diabetic males suffering from diabetic neuropathy aged(40_60)years old

Nerve Growth Factor OTHER

nerve growth factor level using its corresponding ELISA kit

type 2 diabetic male not suffering from diabetic neuropathy aged(40-60) years old

25(OH) vitamin D OTHER

25(OH) vitamin D serum level using its corresponding ELISA kit

control group

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Group І: Control group included non-diabetic healthy males. Group П: Type 2 male diabetic patients not suffering from diabetic neuropathy in Aswan University Hospital of matched age. Group III: Type 2 male diabetic patients suffering from diabetic neuropathy in Aswan University Hospital of matched age.

You may qualify if:

• Adult male patients 40 -65 years' old who have type 2 diabetes mellitus on oral hypoglycemic , non-diabetic healthy subjects of matched age and type 2male diabetic neuropathy patients of matched age .

You may not qualify if:

• Cardiac patients.
• Patients who have transient ischemic attack or stroke.
• Patients with inflammatory rheumatic diseases.
• Patients with malignant diseases.
• Hyperparathyroidism.
• Hypothyroidism.
• Renal impairment with renal replacement therapy.
• Liver diseases.
• Patients on vitamin D supplementation.
• Patients on vitamin B12 supplementation.

Sponsors & Collaborators

• Aswan University: lead

Study Sites (2)

Aswan university hospital

Aswān, Aswan Governorate, 81157, Egypt

Location

Aswan university hospital

Aswān, Aswan Governorate, Aswan, Egypt

Location

Related Publications (2)

• Shafiee A, Rafiei MA, Jafarabady K, Eskandari A, Abhari FS, Sattari MA, Amini MJ, Bakhtiyari M. Effect of cannabis use on blood levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF): A systematic review and meta-analysis. Brain Behav. 2024 Jan;14(1):e3340. doi: 10.1002/brb3.3340.

  PMID: 38376038 RESULT

• Pittas AG, Jorde R, Kawahara T, Dawson-Hughes B. Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D? J Clin Endocrinol Metab. 2020 Dec 1;105(12):3721-33. doi: 10.1210/clinem/dgaa594.

  PMID: 32844212 RESULT

Related Links

• Related Info

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood samples

MeSH Terms

Conditions

Diabetic Neuropathies; Hereditary Sensory and Autonomic Neuropathies

Interventions

Nerve Growth Factor; Vitamin D

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases; Nervous System Malformations; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Polyneuropathies; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn

Intervention Hierarchy (Ancestors)

Nerve Growth Factors; Intercellular Signaling Peptides and Proteins; Peptides; Amino Acids, Peptides, and Proteins; Proteins; Nerve Tissue Proteins; Biological Factors; Secosteroids; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Central Study Contacts

Marwa Nasry Elbadry, physiology demonstrator

CONTACT

02+01126060796; marwanasry666@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Instructor of medical physiology

Study Record Dates

• First Submitted: November 15, 2025
• First Posted: November 19, 2025
• Study Start: December 1, 2025
• Primary Completion: February 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-11

Locations

EG (2)