Impact of Subclinical Hypothyroidism on Liver Enzymes and Lipid Profile

NCT07236697 | Not Yet Recruiting

• 1 other identifier: 04-2025-201491
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

the goal of the randomized controlled observational study is to observe the effect of subclinical hypothyroidism on liver enzymes and lipid profile

Conditions

Subclinical Hypothyroidism

Keywords

subclinical hypothyroidism on liver enzymes and lipid profile

Outcome Measures

Primary Outcomes (1)

• Impact of Subclinical Hypothyroidism on Liver Enzymes and Lipid Profile

  1. Mean levels of liver enzymes (ALT, AST, GGT) • To determine whether there is a statistically significant difference in liver enzyme levels between individuals with subclinical hypothyroidism and euthyroid controls. 2. Mean values of lipid profile components (Total Cholesterol, LDL-C, HDL-C, Triglycerides) • To assess whether subclinical hypothyroidism is associated with dyslipidemia compared to the control group.

  Baseline

Interventions

liver enzymes DIAGNOSTIC_TEST

subclinical hypothyroidism on liver enzymes and lipid profile

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

internal medicine department

You may qualify if:

• Age ≥ 18 years
• For SCH group: Elevated TSH with normal FT4
• For control group: Normal TSH and FT4 levels

You may not qualify if:

• Evident hypothyroidism or hyperthyroidism
• Diagnosed with diabetes mellitus
• Chronic liver disease
• Chronic kidney disease
• Use of lipid-lowering or thyroid medications
• Pregnancy
• Alcohol abuse

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut university hospitals

Asyut, Egypt

Location

Related Publications (2)

• Shan Z, Chen L, Lian X, Liu C, Shi B, Shi L, Tong N, Wang S, Weng J, Zhao J, Teng X, Yu X, Lai Y, Wang W, Li C, Mao J, Li Y, Fan C, Teng W. Iodine Status and Prevalence of Thyroid Disorders After Introduction of Mandatory Universal Salt Iodization for 16 Years in China: A Cross-Sectional Study in 10 Cities. Thyroid. 2016 Aug;26(8):1125-30. doi: 10.1089/thy.2015.0613. Epub 2016 Jul 22.

  PMID: 27370068 RESULT

• Mavromati M, Jornayvaz FR. Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD. Int J Mol Sci. 2021 Nov 26;22(23):12797. doi: 10.3390/ijms222312797.

  PMID: 34884625 RESULT

Related Links

• Unraveling the Role of Hypothyroidism in Non-alcoholic Fatty Liver Disease Pathogenesis: Correlations, Conflicts, and the Current Stand

Study Officials

• Muhammad Abbas Said, professor

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

shahd ali resident, BM

CONTACT

01020111527; sh.ja.me2015@gmail.com

hanaa mohamed lecturer, MD

CONTACT

01094608083; hanaaried@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: November 15, 2025
• First Posted: November 19, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-09

Locations

EG (1)