Predictors of Post-Thrombectomy Cognitive Impairment in Acute Ischemic Stroke Patients
1 other identifier
observational
120
0 countries
N/A
Brief Summary
This prospective cohort study investigates predictors of post-stroke cognitive impairment (PSCI) in patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke due to large vessel occlusion. Adult patients with successful reperfusion (mTICI 2b-3) will be followed at 3 and 6 months to assess cognition, functional recovery, and depression. Predictors across clinical, procedural, radiological, and laboratory domains will be analyzed. The study aims to identify risk factors for PSCI, estimate its prevalence, and evaluate its impact on outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2025
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 19, 2025
CompletedFirst Posted
Study publicly available on registry
November 19, 2025
CompletedStudy Start
First participant enrolled
December 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 15, 2028
November 19, 2025
September 1, 2025
2.1 years
September 19, 2025
November 17, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Cognitive impairment after thrombectomy (MoCA)
Cognitive status will be assessed using the Arabic version of the Montreal Cognitive Assessment (MoCA, score range 0-30, with scores \<26 indicating impairment). The primary outcome will be the prevalence of post-stroke cognitive impairment (PSCI) among thrombectomy patients.
3 months (±2 weeks) and 6 months (±2 weeks) post-thrombectomy
Secondary Outcomes (9)
Domain-specific cognitive performance (OCS)
3 months (±2 weeks) and 6 months (±2 weeks) post-thrombectomy
Depression and anxiety symptoms (HADS)
3 months (±2 weeks) and 6 months (±2 weeks) post-thrombectomy
Functional independence (Barthel Index)
3 months (±2 weeks) and 6 months (±2 weeks) post-thrombectomy
Global disability (modified Rankin Scale)
3 months (±2 weeks) and 6 months (±2 weeks) post-thrombectomy
Infarct volume (DWI MRI)
Within 24-72 hours post-thrombectomy
- +4 more secondary outcomes
Study Arms (1)
Postthrombectomy
All patients wgo underwent endovascular thrombectomy under standard care will be assessed for cognitive function at 3 time points
Eligibility Criteria
As described in inclusion/exclusion criteria
You may qualify if:
- Adults (≥18 years).
- Acute ischemic stroke due to anterior circulation LVO confirmed by imaging undergoing EVT per guidelines.
- Successful reperfusion (mTICI 2b-3)
- Able to provide consent.
You may not qualify if:
- Severe aphasia/coma interfering with cognitive assessment.
- Pre-existing dementia ( using Arabic version of the Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly).
- Non-ischemic etiology.
- Death within 72 hours.
- Refusal to participate in the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant lecturer
Study Record Dates
First Submitted
September 19, 2025
First Posted
November 19, 2025
Study Start
December 1, 2025
Primary Completion (Estimated)
December 30, 2027
Study Completion (Estimated)
January 15, 2028
Last Updated
November 19, 2025
Record last verified: 2025-09