Prevalence of H. Pylori in Stomach Cancers in the West Indies

NCT07233447 | Recruiting

• 1 other identifier: PAP_RIPH2_2020/27
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 2

Brief Summary

The incidence and mortality of stomach cancer are higher in the French West Indies than in mainland France. The prevalence of H. pylori infection associated with this cancer remains unknown in these populations. The main objective of the study is to estimate the prevalence of H. Pylori detected by immunohistochemistry in patients newly diagnosed with cancer.

Conditions

Oncology Epidemiology; Risk Factors

Keywords

H. Pylori; Guadeloupe; stomach cancer

Outcome Measures

Primary Outcomes (1)

• detection of H. Pylori in immunohistochemistry

  Detection of Helicobacter pylori will be performed by immunohistochemistry (IHC) on gastric biopsy samples collected at inclusion. The procedure aims to identify the presence of H. pylori antigens within the gastric mucosa using specific antibodies. The test will be conducted in a certified pathology laboratory according to standard diagnostic protocols. Results will be reported as positive or negative for H. pylori infection.

  Baseline

Secondary Outcomes (1)

• positivity of anti H. Hylori serology by Elisa test

  Baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients living in Guadeloupe for more than 6 months, referred to the gastroenterology departments of the University Hospital of Guadeloupe (CHUG) and to the gastroenterology practice of Dr. Durand, with an endoscopic diagnosis of gastric cancer confirmed by histopathological examination in one of the three endoscopy centers (CHUG, Polyclinique de la Guadeloupe, and Clinique des Eaux Claires), will be invited to participate in the study following their disclosure consultation.

You may qualify if:

• Patient over 18 years of age residing in Guadeloupe for more than 6 months and with a primary diagnosis of gastric cancer
• Patient having read the information note and having signed the consent to participate in the study
• Patient with social security coverage.

You may not qualify if:

• Refusal to participate.
• Patient who could not answer the questionnaires
• Patient not affiliated to a social security scheme
• Patient under legal protection (judicial safeguard, guardianship, curatorship, etc.)
• Pregnant or breastfeeding woman

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead

Study Sites (2)

Cabinet Galeries de Houelbourg

Baie-Mahault, 97122, Guadeloupe

RECRUITING

CHU de la Guadeloupe

Pointe-à-Pitre, 97159, Guadeloupe

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

The biological samples (serum, DNA, tumor) will be processed and stored for future research. The collection will be used for future somatic genetic analyses aimed at identifying additional disease-related risk factors. No analyses of constitutional (germline) genetic characteristics will be performed.

MeSH Terms

Conditions

Stomach Neoplasms

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases

Study Officials

• Jacqueline Deloumeaux, MD PhD

  CHU de la Guadeloupe

  STUDY DIRECTOR

• Moana GELU-SIMEON, MD PhD

  CHU de la Guadeloupe

  STUDY CHAIR

Central Study Contacts

Mélanie petapermal, Master degree

CONTACT

+590590934667; melanie.petapermal@chu-guadeloupe.fr

Valérie Hamony Soter

CONTACT

+590590934677; valerie.soter@chu-guadeloupe.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 18, 2025
• Study Start: February 24, 2025
• Primary Completion (Estimated): February 24, 2027
• Study Completion (Estimated): February 24, 2027
• Last Updated: November 18, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

GU (2)