A Study to Evaluate the Safety of Increasing Doses of DF5112 in Healthy Adults

NCT07232121 | Recruiting Phase 1

• 1 other identifier: DF5112-001
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

This is a double-blind, randomized, placebo-controlled, single ascending dose (SAD) study to evaluate safety, tolerability, pharmacokinetics (PK), immunogenicity and pharmacodynamics (PD) of DF5112 in healthy adult participants. A total of 48 participants are planned to be randomized into 6 cohorts. Additional cohorts at intermediate dose levels may be evaluated. Each cohort will include 8 healthy participants randomized to receive DF5112 or placebo through intravenous (IV) or subcutaneous (SC) administration. Following dose administration participants will be confined at the clinical research unit for observation for approximately 1 week and then will return for subsequent pre-identified follow up visits through Day 29.

Conditions

Healthy Participants; Healthy Adult Females; Healthy Adult Male; Healthy; Volunteer

Keywords

Healthy Volunteer; Healthy Participant

Outcome Measures

Primary Outcomes (1)

• Number of participants with Treatment Emergent Adverse Events as Assessed by Common Terminology Criteria for Adverse Events (CTCAE) v5.0

  From Day 1 dosing to end of study at Day 29

Secondary Outcomes (2)

• To evaluate the PK of single ascending doses of DF5112 administered by IV or SC injection

  From Day 1 dosing to end of study at Day 29

• Incidence and titer of Anti-Drug Antibodies

  From Day 1 dosing to end of study at Day 29

Study Arms (2)

DF5112

EXPERIMENTAL

Single dose of DF5112 administered either via IV or SC

Drug: DF5112

Placebo

PLACEBO COMPARATOR

Single dose of placebo administered either via IV or SC

Other: Placebo

Interventions

DF5112 DRUG

DF5112 administered IV or SC

DF5112

Placebo OTHER

Placebo administered IV or SC.

Placebo

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female participants aged 18 to 55 years (inclusive) at the time of informed consent.
• Body mass index (BMI) between ≥ 18.0 and ≤ 32.0 kg/m2 and body weight ≥ 45 kg.
• At the discretion of the Principal Investigator (PI) or designee, in good general health, with no significant medical history, and have no clinically significant abnormalities on physical examination at Screening and/or before the first administration of IP.
• Clinical laboratory values within normal range as specified by the testing laboratory, unless deemed not clinically significant by the PI or designee.

You may not qualify if:

• History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrinological, hematological, or neurological disorders that, in the opinion of the PI or designee, are capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study intervention; or interfering with the interpretation of data.
• History of lymphoproliferative disease or any known malignancy or history of malignancy of any organ system treated or untreated within the past 5 years, regardless of whether there is evidence of local recurrence or metastases (except for squamous and basal cell carcinoma of the skin or actinic keratoses that have been treated with no evidence of recurrence in the past 12 weeks; carcinoma in situ of the cervix or non-invasive malignant colon polyps that have been removed).
• History of or evidence of recurrent or chronic bacterial or fungal infections including those of the skin, vagina, oral cavity, etc., or systemic fungal infection.
• History of unexplained, recurrent infection, or infection requiring treatment with systemic antibiotics within 90 days prior to dosing on Day 1.
• Active oral infection.
• Acute illness (e.g. common cold) within 2 weeks prior to Screening, or seasonal influenza or COVID within 4 weeks prior to Screening.
• History of latent or active tuberculosis that has not been adequately treated, at the discretion of the PI or designee.
• Positive or inconclusive hepatitis B or hepatitis C based antibody tests at Screening.
• Positive human immunodeficiency virus (HIV) antibody test at Screening.
• History of severe allergy, hypersensitivity reaction, or anaphylaxis to drugs or human proteins or components of the study drug formulation used in this study.
• Any vaccination within 1 month of Day 1 and planned within 1 month post Day 1. Any live or attenuated vaccine within 1 month prior to Day 1 and planned within 3 months post Day 1.

Sponsors & Collaborators

• Dragonfly Therapeutics: lead

Study Sites (1)

Scientia Clinical Research Ltd

Sydney, New South Wales, 2031, Australia

RECRUITING

Central Study Contacts

Christopher Argent

CONTACT

+61 2 9382 5844; christopher.argent@scientiaclinicalresearch.com.au

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Double-blind
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 13, 2025
• First Posted: November 18, 2025
• Study Start: January 12, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 1, 2026

Record last verified: 2026-03

Locations

AU (1)