Chlordecone Exposure and Female Fertility

NCT07231510 | Recruiting

• 2 other identifiers: PAP_RIPH2_2023/082023-A01755-40
• Study Type: observational
• Target: 634
• Locations: 1 country
• Sites: 1

Brief Summary

Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer. Due to its very long persistence the population continues to be exposed to this chemical through their food consumptions. Although, chlordecone have been associated in animal study impairment of ovarian reserve, to date, no study has been published concerning the link between chlordecone exposure and female fertility. The main objective of this project is to study the association between chlordecone exposure and anti-mullerian hormone (AMH) in women consulting for couple infertility in Guadeloupe.

Conditions

Infertility Female

Keywords

polycystic ovarian syndrome; endometriosis; female infertility,; ovarian reserve; environmental exposures; chlordecone; kepone

Outcome Measures

Primary Outcomes (1)

• Levels of AMH according to terciles of chlordecone levels.

  The purpose is to study the association between chlordecone exposure and AMH levels in women consulting for couple infertility in Guadeloupe.

  AMH levels will be measured during the assessment conducted for assisted reproductive technology (ART) and will date from less than one year before inclusion

Secondary Outcomes (4)

• Number of antral follicles according to terciles of chlordecone levels.

  between days 2 and 4 of the spontaneous menstrual cycle

• AMH levels and antral follicle count according to the levels of other POPs

  baseline

• relationship between exposure to chlordecone and other POPs and the risk of the main causes of female infertility

  baseline

• Chlordecone levels according to the outcomes of IVF/ICSI management:

  changes from baseline to 2 years after

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women consulting for couple infertility in Guadeloupe.

You may qualify if:

• Women aged from 18 to 39 years
• Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe
• Free, informed and written consent

You may not qualify if:

• Women aged from 18 to 39 years
• Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe
• Free, informed and written consent

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead
• Institut Pasteur de Guadeloupe: collaborator
• Rennes University Hospital: collaborator

Study Sites (1)

Chu de La Guadeloupe

Pointe-à-Pitre, 97159, Guadeloupe

RECRUITING

MeSH Terms

Conditions

Infertility, Female; Polycystic Ovary Syndrome; Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Infertility; Ovarian Cysts; Cysts; Neoplasms; Ovarian Diseases; Adnexal Diseases; Gonadal Disorders; Endocrine System Diseases

Study Officials

• Ronan Garlantezec, MD PhD

  CHU de Rennes - Université de Rennes

  STUDY DIRECTOR

Central Study Contacts

Mélanie petapermal

CONTACT

+590590934667; melanie.petapermal@chu-guadeloupe.fr

Valérie Hamony Soter

CONTACT

+590590934677; valerie.soter@chu-guadeloupe.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 17, 2025
• Study Start: January 26, 2024
• Primary Completion: January 26, 2026
• Study Completion (Estimated): January 26, 2028
• Last Updated: November 17, 2025

Record last verified: 2025-11

Locations

GU (1)