The Effect of Glucomannan Powder on Improving Gut Microbiota.

NCT07231003 | Active Not Recruiting DMC

• 1 other identifier: lin5611_03
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The object of this study is evaluating the effects of the Glucommanan on the healthy human subjects who are. In this trial, at most 30 healthy subjects whose ages are 20\~65 years old (15 for placebo and 15 for intervention)will be included. The total experiment will be 9 weeks and the intervention period will be 6 weeks, within which, at week 0, 6, and 7, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST, also known as GOT), alanine aminotransferase (ALT, also known as GPT), blood urea nitrogen (BUN), serum creatinine (Cr), fasting blood glucose (Glucose, AC) and adiponectin would be measured. Feces samples and anthropometric data will also be acquired. The results will be analyzed according to the methods published by the Ministry of Health and Welfare of Taiwan Food and Drug Administration.

Conditions

Dysbiosis

Keywords

dysbiosis; Glucomannan; gut-microbiota

Outcome Measures

Primary Outcomes (1)

• gut microbiota

  Evaluation of Gut Microbiota by Analysis of Four Indicator Strains and 16S rRNA Sequencing Using Fecal Samples

  Week(0) (Baseline), Wk(6),Wk7

Study Arms (2)

Placebo group

PLACEBO COMPARATOR

2 packs of corn starch daily

Dietary Supplement: Placebo

Intervention group

EXPERIMENTAL

2 packs of glucomannan powder daily

Dietary Supplement: Glucomannan

Interventions

Glucomannan DIETARY_SUPPLEMENT

2 packs of glucomannan, 2 grams per pack

Intervention group

Placebo DIETARY_SUPPLEMENT

2 packs of corn starch, 2 grams per pack

Placebo group

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Both genders, aged between 20 and 65 years.
• No history of gastrointestinal disorders or other significant health issues.
• Overall good health.

You may not qualify if:

• \- Participants who have taken antibiotics or any medications/supplements that could affect the gut microbiota within 1 week prior to the experiment or during the study.
• Pregnant or breastfeeding women.
• Smokers or individuals with excessive alcohol consumption.
• Chronic disease medication usage for less than 3 months.
• Postmenopausal women on hormone replacement therapy.
• Individuals with acute illnesses such as a cold.

Sponsors & Collaborators

• Taipei Medical University: lead

Study Sites (1)

Taipei Medical University

Taipei, Taiwan

Location

MeSH Terms

Conditions

Dysbiosis

Interventions

(1-6)-alpha-glucomannan

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 13, 2025
• First Posted: November 17, 2025
• Study Start: August 28, 2025
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: November 17, 2025

Record last verified: 2025-11

Locations

TW (1)