Evaluating Mammography Communication Approaches

NCT07228234 | Active Not Recruiting

• 2 other identifiers: 25-0635.ccR37CA254926
• Study Type: interventional
• Target: 1,900
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized online experiment testing different methods for communicating about the benefits and harms of breast cancer screening. Participants will be randomly assigned to experimental conditions which vary whether screening outcomes are referred to as "benefits and harms" vs. "outcomes that can happen with screening", and vary the presence or absence of information about improvements in breast cancer survivability. In a control condition, participants receive basic information about what mammography is (which is also information received in all other conditions). Primary outcomes include skepticism toward the information presented, and screening intentions.

Conditions

The Focus of This Study is to Identify How Different Approaches to Mammography Communication Affect Skepticism Toward Mammography Evidence

Keywords

Communication; Mammography

Outcome Measures

Primary Outcomes (1)

• Skepticism toward the screening message

  Skepticism toward the screening message is assessed using the RED scale, consisting of 11 questions each measured on a 7-point Likert scale

  Participant experience entails a one-time survey. This outcome is measured in that survey, immediately after participants read information about mammography screening.

Study Arms (5)

Control condition

EXPERIMENTAL

Participants receive basic information about what mammography screening is

Other: No intervention

Harm/benefit language, survivability information

EXPERIMENTAL

Outcomes of screening are referred to as "harms" and "benefits"; information about breast cancer survivability is included

Other: Harm/benefit language vs. outcomes that can happen; Other: Breast cancer survivability information

Harm/benefit language, no survivability information

EXPERIMENTAL

Outcomes of screening are referred to as "harms" and "benefits"; information about breast cancer survivability is not included

Other: Harm/benefit language vs. outcomes that can happen

Outcomes that can happen language, survivability information

EXPERIMENTAL

Outcomes of screening are referred to as "outcomes that can happen"; information about breast cancer survivability is included

Other: Harm/benefit language vs. outcomes that can happen; Other: Breast cancer survivability information

Outcomes that can happen language, no survivability information

EXPERIMENTAL

Outcomes of screening are referred to as "outcomes that can happen"; information about breast cancer survivability is not included

Other: Harm/benefit language vs. outcomes that can happen

Interventions

Breast cancer survivability information OTHER

Information about improvements over time in the survivability of breast cancer is provided vs. not

Harm/benefit language, survivability information; Outcomes that can happen language, survivability information

No intervention OTHER

This is the control condition in which only basic information about mammography screening.

Control condition

Harm/benefit language vs. outcomes that can happen OTHER

Information about mortality benefit, false positives and overdiagnosis are referred to throughout the communication as either "harms" and "benefits" or "outcomes that can happen".

Harm/benefit language, no survivability information; Harm/benefit language, survivability information; Outcomes that can happen language, no survivability information; Outcomes that can happen language, survivability information

Eligibility Criteria

• Age: 39 Years - 49 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Female, age 39-49

You may not qualify if:

• No history of breast cancer, no known BRCA1/2 gene mutation

Sponsors & Collaborators

• University of Colorado, Denver: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

University of Colorado Anschutz

Aurora, Colorado, 80045, United States

Location

MeSH Terms

Conditions

Communication

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This is a 2 x 2 +1 randomized factorial design. Participants will be randomly assigned to 1 of 5 experimental conditions, which vary (1) whether screening outcomes are referred to as "benefits and harms" vs. "outcomes that can happen with screening", and (2) the presence or absence of information about improvements in breast cancer treatment and survivability. In a 5th arm, a control condition, participants receive basic information about what mammography is (which is also information received in all other conditions).

Study Record Dates

• First Submitted: November 11, 2025
• First Posted: November 14, 2025
• Study Start: November 6, 2025
• Primary Completion: November 12, 2025
• Study Completion (Estimated): November 30, 2027
• Last Updated: April 1, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
• Time Frame: This information will be made publicly available on the Open Science Framework prior to publishing the a manuscript from these data.
• Access Criteria: Anyone will be able to access the IPD via the Open Science Framework.

Locations

US (1)