A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer
Trial of Meaning Centered Psychotherapy for Mexican Patients With Advanced Cancer
1 other identifier
interventional
300
2 countries
2
Brief Summary
The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, including how the therapy is designed, outside factors, available resources, and how the people involved affect how well MCP-L works.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable breast-cancer
Started Jun 2026
Typical duration for not_applicable breast-cancer
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 15, 2025
CompletedFirst Posted
Study publicly available on registry
November 6, 2025
CompletedStudy Start
First participant enrolled
June 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 13, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 13, 2029
June 4, 2026
June 1, 2026
2.9 years
October 15, 2025
June 3, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in clinical levels of anxiety and depression for participants participating in Meaning-Centered Psychotherapy for Latinos (MCP-L)
To examine the efficacy of Meaning-Centered Psychotherapy for Latinos (MCP-L) in improving clinical levels of anxiety and depression at 1-month post-intervention follow-up. Assessed using the General Anxiety Disorder 7-item scale (GAD-7; range 0-21, higher scores indicate greater anxiety levels) and the Patient Health Questionnaire 9-item scale (PHQ-9; range 0-27, higher scores indicate greater depression levels), respectively.
1 month
Change in clinical levels of anxiety and depression for participants participating in Meaning-Centered Psychotherapy for Latinos (MCP-L)
To examine the efficacy of Meaning-Centered Psychotherapy for Latinos (MCP-L) in improving clinical levels of anxiety and depression at 3-month post-intervention follow-up. Assessed using the General Anxiety Disorder 7-item scale (GAD-7; range 0-21, higher scores indicate greater anxiety levels) and the Patient Health Questionnaire 9-item scale (PHQ-9; range 0-27, higher scores indicate greater depression levels), respectively.
3 months
Study Arms (2)
Experimental Intervention
EXPERIMENTALMeaning-Centered Psychotherapy for Latinos (MCP-L)
Control Intervention
NO INTERVENTIONCognitive Behavioral Therapy (CBT)
Interventions
MCP-L is a structured 7-session manualized intervention culturally adapted into Spanish for Latino participants diagnosed with advanced cancer, which utilizes a mixture of didactics, discussion and experiential exercises that focus on particular themes related to meaning and advanced cancer. It is 60-minute individual sessions delivered every week or intermittently (depending on participant preference) for up to approximately 3 months (in this time period) in the event of medical illness.
Eligibility Criteria
You may qualify if:
- EMR Criteria
- \- Documentation of Disease
- Pathologically confirmed breast, prostate, colorectal, thyroid, cervix, uteri, or lung - solid tumor cancer (either most recent or new diagnosis)
- Definition of Disease \[or Measurable Disease\]
- Diagnosed with stages III or IV
- Prior Treatment
- Receiving ambulatory care at INCan
- Self-Report Criteria
- Age ≥ 18 years
- Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
- Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
- Providing care (or services) to Mexican cancer patients at INCan
- Has access to internet and an electronic device
- Agrees to be audio-recorded
You may not qualify if:
- EMR Criteria
- Prior Treatment
- Received psychological or psychiatric care at INCan in the last 3 months
- In the judgment of the treating physician, protocol investigators, and/or study staff, presence of cognitive impairment (e.g., delirium or dementia) sufficient to preclude meaningful informed consent and/or study participation
- Diagnosed with a serious psychiatric condition
- Self-Report Criteria
- Received psychological or psychiatric care outside of INCan in the last 3 months
- Presence of suicide risk determined by the Columbia-Suicide Severity Rating Scale
- Too ill to participate determined by the question: "Do you feel too ill to participate because of communication problems, uncontrollable pain, or other symptoms that prevent you from participating?"
- Provider Eligibility Criteria:
- Age ≥ 18 years
- Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
- Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
- Providing care (or services) to Mexican cancer patients at INCan
- Has access to internet and an electronic device
- +1 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
Instituto Nacional de Cancerología (INCan)
Mexico City, Mexico
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rosario Costas Muniz, PhD
Memorial Sloan Kettering Cancer Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 15, 2025
First Posted
November 6, 2025
Study Start
June 1, 2026
Primary Completion (Estimated)
April 13, 2029
Study Completion (Estimated)
April 13, 2029
Last Updated
June 4, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will share
Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.