NCT07220980

Brief Summary

The goal of this clinical trial is to learn when is the best time to remove a Foley catheter (tube used to drain urine from the bladder) after surgery in adult men who have a specific type of urethral stricture disease (narrowing of the tube that carries urine from the body). The main question it aims to answer is: \- Is there a difference between removing the catheter at 7-10 days versus 18-21 days? Researchers will compare Foley removal at 7-10 days to removal at 18-21 days to see if there is a difference in problems after surgery or if the narrowing returns. Participants will:

  • Complete a survey before surgery, when the catheter is removed, and within 12 months after surgery
  • Complete follow-up visits after surgery based on your specific medical needs and standard of care

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
320

participants targeted

Target at P75+ for not_applicable

Timeline
16mo left

Started Aug 2024

Typical duration for not_applicable

Geographic Reach
1 country

4 active sites

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress56%
Aug 2024Sep 2027

Study Start

First participant enrolled

August 28, 2024

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

October 22, 2025

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 27, 2025

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2027

Last Updated

February 27, 2026

Status Verified

December 1, 2025

Enrollment Period

3 years

First QC Date

October 22, 2025

Last Update Submit

February 24, 2026

Conditions

Outcome Measures

Primary Outcomes (2)

  • Number of Participants who Experience a Stricture Recurrence

    1 year

  • Number of Participants who Experience a Perioperative Complication

    From Foley insertion to Foley removal

Secondary Outcomes (1)

  • Rate of Retrograde Urethrograms Performed on Day of Foley Removal

    Foley Removal

Study Arms (2)

Early Removal

EXPERIMENTAL
Device: Early catheter removal

Later Removal

EXPERIMENTAL
Device: Later catheter removal

Interventions

Removal after 7-10 days

Early Removal

Removal after 18-21 days

Later Removal

Eligibility Criteria

Age18 Years - 70 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Cis-male patients
  • Age 18-70, inclusive
  • Bulbar urethral stricture undergoing a urethroplasty
  • Urethral stricture defect less than or equal to 7cm in length
  • First time urethroplasty
  • Negative urine analysis or urine culture

You may not qualify if:

  • History of pelvic radiation
  • Diabetes with Hba1c greater than 8%
  • Penile urethral stricture
  • Posterior urethroplasty
  • Bulbar stricture greater than 7cm

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Lahey Hospital & Medical Center

Burlington, Massachusetts, 01805, United States

Location

Western New York Urology Associates

Buffalo, New York, 14203, United States

Location

Ohio State University

Columbus, Ohio, 43212, United States

Location

University of Utah Hospital

Salt Lake City, Utah, 84132, United States

Location

MeSH Terms

Conditions

Urethral Stricture

Condition Hierarchy (Ancestors)

Urethral ObstructionUrethral DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 22, 2025

First Posted

October 27, 2025

Study Start

August 28, 2024

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

September 1, 2027

Last Updated

February 27, 2026

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations