Virtual Reality Viewing of Unaltered Streetscape Versus Digitally Manipulated Opposite Streetscape to Assess Psychosocial Response in Participants

NCT07216534 | Recruiting

• 2 other identifiers: OSU-25170NCI-2025-07331
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial compares virtual reality viewing of an unaltered streetscape versus a digitally manipulated opposite streetscape to assess the psychosocial response in participants. Visible measures of neighborhood factors might be associated with health outcomes and risk factors of those outcomes. Short-term exposure to virtual reality environments representing very high or very low levels of neighborhood physical disorder - presence or absence of garbage/litter, presence or absence of graffiti, presence or absence of an abandoned building, presence or absence of large dumpsters, poor or very well-kept building conditions, poor or very well-kept yard conditions, poor or very well-kept road verge conditions may be a safe and effective way to assess psychosocial response in participants.

Conditions

Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm; Psychiatric Disorder

Outcome Measures

Primary Outcomes (5)

• Change in heart rate variability

  Mean heart rate variability over the entire session of each VR condition will be calculated from electrocardiograph data. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.

  From baseline to completion of virtual reality (VR) viewings, up to 1 day

• Change in skin conductance

  Skin conductance, measured as microsiemens, will be calculated as the mean value over each VR condition. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.

  From baseline to completion of VR viewings, up to 1 day

• Affective reaction

  Assessed via Self-assessment Manikin. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.

  After completion of VR viewings, up to 1 day

• Anxiety

  Assessed via Spielberger State-Trait Anxiety Inventory short form. Will compare the difference between two VR conditions (viewing opposite neighborhood image versus viewing twin neighborhood image) using a crossover design. Analyses of outcomes will be conducted using generalized linear mixed model approaches.

  After completion of VR viewings, up to 1 day

• Participant reported discomfort

  This is an open-ended outcome measure. Discomfort reported by participants will be recorded by study staff.

  After completion of VR viewings, up to 1 day

Study Arms (2)

Arm I (twin followed by opposite streetscape)

EXPERIMENTAL

Participants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes followed by viewing their streetscape with the opposite physical disorder using VR for up to 5 minutes.

Other: Survey Administration; Other: Virtual Technology Intervention

Arm II (opposite followed by twin streetscape)

EXPERIMENTAL

Participants have their streetscape photographed. Participants view a standard residential streetscape using VR for up to 5 minutes. Patients then view their streetscape with the opposite physical disorder using VR for up to 5 minutes followed by viewing a digital twin of their streetscape with identical physical disorder using VR for up to 5 minutes.

Other: Survey Administration; Other: Virtual Technology Intervention

Interventions

Survey Administration OTHER

Ancillary studies

Arm I (twin followed by opposite streetscape); Arm II (opposite followed by twin streetscape)

Virtual Technology Intervention OTHER

View standard streetscape

Also known as: Virtual Reality Intervention, Virtual Technology

Arm I (twin followed by opposite streetscape); Arm II (opposite followed by twin streetscape)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults 18+
• Must currently live (4+ night/week) at the residence being studied. Only one resident per household will be selected
• Must understand and be able to read English
• Must agree to have residence photographed
• Must be able to wear a VR head mounted display
• Must live in neighborhood that has been selected for study
• Must be willing and able to attend an approximately 2 hour in-person visit on Ohio State University (OSU) campus

You may not qualify if:

• Pregnant women
• Visual or mobility impairment
• Cannot have epilepsy or other condition that would inhibit them from being able to use a VR headset

Sponsors & Collaborators

• Ohio State University Comprehensive Cancer Center: lead

Study Sites (1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

Related Links

• The Jamesline

MeSH Terms

Conditions

Mental Disorders

Study Officials

• Jesse Plascak, PhD, MPH

  Ohio State University Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

The Ohio State University Comprehensive Cancer Center

CONTACT

800-293-5066; OSUCCCClinicaltrials@osumc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 10, 2025
• First Posted: October 14, 2025
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 21, 2026

Record last verified: 2026-04

Locations

US (1)