Low-Flow Desflurane Anesthesia and Its Effects on BIS and Postoperative Cognitive Functions

NCT07212543 | Active Not Recruiting

• 1 other identifier: 2025-05/73
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the effects of low-flow desflurane anesthesia in adult patients undergoing major abdominal surgery. The researchers will examine whether different low-flow strategies: Cause differences in the Bispectral Index (BIS), which measures brain activity during anesthesia, Affect postoperative cognitive functions such as memory and attention. Participants will: Receive desflurane anesthesia during surgery, Have anesthesia delivered at different low-flow rates, Have their BIS values monitored throughout the operation, Complete tests after surgery to evaluate their cognitive functions. This research will help determine the safety of different low-flow strategies and their impact on patients' cognitive recovery after surgery.

Conditions

Major Abdominal Surgeries

Keywords

Low-flow anesthesia.; Desflurane; Major abdominal surgery; Bispectral Index (BIS)

Outcome Measures

Primary Outcomes (1)

• Change from Baseline in Mini-Mental State Examination (MMSE) Score Postoperatively

  Measure: Change in cognitive function assessed by the Mini-Mental State Examination (MMSE) Time Frame: From baseline (preoperative assessment) to postoperative assessment (within 24 hours after surgery) Description: The MMSE will be used to evaluate changes in cognitive function in patients receiving desflurane anesthesia at different low-flow rates. The primary endpoint is the difference between preoperative and postoperative MMSE scores.

  From baseline (preoperative assessment, within 24 hours before surgery) to postoperative assessments at 24 hours and 7 days after surgery

Study Arms (1)

Group 1 :desflurane 0.5 L/min Group 2 :desflurane 1 L/min Group 3 : desflurane 1.5 L/min

This cohort includes adult patients undergoing major abdominal surgery whose general anesthesia is maintained with desflurane using different low-flow strategies. The main intervention of interest is the variation in fresh gas flow rates. Participants will be divided into three subgroups according to the applied flow rate: 0.5 L/min desflurane anesthesia 1.0 L/min desflurane anesthesia 1.5 L/min desflurane anesthesia During surgery, the depth of anesthesia will be continuously monitored using the Bispectral Index (BIS). Cognitive function will be assessed both preoperatively and postoperatively with the Mini-Mental State Examination (MMSE). This design will allow comparison of the effects of different low-flow strategies on intraoperative BIS values as well as on cognitive function changes before and after surgery.

Other: Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study.

Interventions

Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study. OTHER

Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study.

Group 1 :desflurane 0.5 L/min Group 2 :desflurane 1 L/min Group 3 : desflurane 1.5 L/min

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will be recruited from patients undergoing elective major abdominal surgery at the Department of Anesthesiology and Reanimation, Ankara Dr Abdurrahman Yurtaslan Onkology Training and Research Hospital.

You may qualify if:

• Patients aged 18-75 years
• ASA physical status I-III
• Scheduled for elective major abdominal surgery
• Provided written informed consent
• Normal preoperative neurocognitive function

You may not qualify if:

• History of neurological or psychiatric disorders
• History of cognitive impairment
• Diagnosed hepatic or renal insufficiency
• Presence of other systemic diseases contraindicating anesthesia

Sponsors & Collaborators

• Dolunay ARIK: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, YENİMAHALLE, 06200, Turkey (Türkiye)

Location

Related Publications (3)

• Bingol Tanriverdi T, Tercan M, Gusun Halitoglu A, Kaya A, Patmano G. Comparison of the Effects of Low-flow and Normal-flow Desflurane Anaesthesia on Inflammatory Parameters in Patients Undergoing Laparoscopic Cholecystectomy. Turk J Anaesthesiol Reanim. 2021 Feb;49(1):18-24. doi: 10.5152/TJAR.2020.30. Epub 2020 Nov 30.

  PMID: 33718901 BACKGROUND

• https://www.researchgate.net/publication/319617159_Low_flow_anesthesia_will_gain_eras_enhanced_recovery_after_surgery

  BACKGROUND

• Baum JA. Low-flow anesthesia: theory, practice, technical preconditions, advantages, and foreign gas accumulation. J Anesth. 1999;13(3):166-74. doi: 10.1007/s005400050050. No abstract available.

  PMID: 14530937 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident Doctor (Anesthesiology)

Study Record Dates

• First Submitted: October 1, 2025
• First Posted: October 8, 2025
• Study Start: May 15, 2025
• Primary Completion: December 20, 2025
• Study Completion: December 21, 2025
• Last Updated: December 9, 2025

Record last verified: 2025-10

Locations

TU (1)