High Intensity Interval Training Versus Moderate Intensity Continuous Training in Frail Elderly

NCT07211334 | Recruiting DMC

• 1 other identifier: Essaiclinique_EPAF
• Study Type: observational
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

The assessment and systematic integration of physical activity into the care pathway of frail elderly people is essential to prevent loss of independence and improve the quality of life of this population. This project, which is part of routine care, aims to evaluate the practices and, in particular, the effects of different types of physical exercise currently in use at the Health and Sport Center of the Grenoble Alpes University Hospital. It therefore aims to optimize professional practices without changing the standard care provided to patients. Recommendations regarding intensity during cardiorespiratory endurance training sessions (moderate to high, taking into account emotional factors) are broad and vary greatly in their application depending on the facilities that work with older adults. This project aims to compare the exercise methods used on ergocycle at Health and Sport Center of Grenoble Alpes University Hospital: high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) to reverse the functional decline that occurs in frail older adults.

Conditions

Frail Elderly

Keywords

Frailty; Elderly; High Intensity Interval Training; Moderate Intensity Continuous Training; Motivation for Physical Activity; Support for Changing Behavior Regarding Physical Activity

Outcome Measures

Primary Outcomes (1)

• Cardiorespiratory endurance (VO2peak)

  in mL/kg/min with an ergospirometer during a maximal progressive test

  At weeks 0, 8 and 24

Secondary Outcomes (7)

• Fried's frailty criteria

  At weeks 0, 8 and 24

• Weight

  At Weeks 0, 8 and 24

• Height

  At weeks 0, 8 and 24

• Body composition

  At weeks 0, 8 and 24

• Health-related quality of life in its physical, psychological, and social dimensions

  At weeks 0, 8 and 24

Interventions

Exercise Training PROCEDURE

Adapted High Intensity Interval Training (HIIT), Moderate-Intensity Continuous training (MICT), therapeutic education workshops to help people become independent regarding their program

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged \>70 years are receiving routine care. They are identified as frail (3 positive criteria out of 5 according to Fried) or pre-frail (1 to 2 positive criteria out of 5 according to Fried) in the Geriatric Department of Grenoble Alpes Universitary Hospital (CHUGA) (Prof. Gavazzi) and are referred to the EXPLORASUD Sport and Health Center at CHU Sud (Dr. Coudurier, Dr. Doutreleau) for support through physical activity.

You may qualify if:

• Adults aged 70 or older;
• Patients meeting at least 1 of 5 frailty criteria (Fried criteria; 2001);
• Patient does not object to the analysis of anonymized data;
• Person affiliated with social security;
• Patient's ability to use an ergocycle safely;
• Patients medically stable patients with no acute illness or recent decompensation that could be aggravated by exercise (at the physician's discretion).

You may not qualify if:

• Unstable medical conditions that may be aggravated by physical activity (as determined by a physician)
• Musculoskeletal disorders and severe neurocognitive conditions that make it impossible to safely use the ergocycle or participate in the exercise program
• individuals participating in other interventional studies or who have recently participated in an interventional study that could influence the results of this study
• Persons referred to in Articles L1121-5 to L1121-8 of the public health code (corresponds to all protected persons: pregnant women, women in labor, breastfeeding mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to legal protection measures)

Sponsors & Collaborators

• University Hospital, Grenoble: lead

Study Sites (1)

University Grenoble alpes

Grenoble, 38043, France

RECRUITING

MeSH Terms

Conditions

Frailty

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Flore PATRICE

CONTACT

04 76 76 72 26; PFlore@chu-grenoble.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: October 7, 2025
• Study Start: December 11, 2025
• Primary Completion (Estimated): February 1, 2028
• Study Completion (Estimated): February 1, 2028
• Last Updated: May 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)