Trials Sponsors Conditions Drugs Pricing

Conditions

Gingival Cleft Orthodontic Space Closure

Keywords

gingival cleftOrthodontic Space Closuregingivagingival diseasetooth extractiontooth socket

Outcome Measures

Primary Outcomes (1)

presence of gingival clefts after space closure initiation
The primary outcome will be the presence of gingival clefts, which will be measured at 3 months and 6 months after space closure initiation
start of canine retraction to its completion (approximately 6 months)

Secondary Outcomes (4)

craniofacial growth pattern
craniofacial growth pattern will be measured at baseline
gingival biotype
At baseline (immediately prior to tooth extraction)
buccal bone dehiscence
Immediately post extraction
canine bulbosity
will be measured at baseline

Study Arms (2)

Early movement group

EXPERIMENTAL

Canine retraction will be started 1 week after extraction

Other: Early space closure

Delayed Movement

EXPERIMENTAL

Canine retraction will be started 8 weeks after extraction

Other: Delayed space closure

Interventions

Early space closureOther

Space closure will be started 1 week after extraction

Early movement group

Delayed space closureOther

Space closure will be started 8 weeks after extraction

Delayed Movement

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Sexall

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

Extraction advised of both first premolars from either maxilla, mandible or both.
All permanent dentition present apart from third molars.

You may not qualify if:

Sponsors & Collaborators

Bahria University
Otherlead

Study Sites (1)

Bahria University of Health Sciences Karachi

Karachi, Sindh, Pakistan

RECRUITING

Ali UmarCONTACT+923345624708 ali.umar1234@yahoo.com

Ali UmarPRINCIPAL INVESTIGATOR

MeSH Terms

Conditions

Gingival Diseases

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic Diseases

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: OUTCOMES ASSESSOR
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Postgraduate Resident

Study Record Dates

First Submitted

August 25, 2025

First Posted

October 7, 2025

Study Start

October 15, 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Gingival Cleft Development at Two Time Points of Canine Retraction

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

Early movement group

Delayed Movement

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Design

Study Record Dates

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

Early movement group

Delayed Movement

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Design

Study Record Dates

Source record

Locations