The Effect of Ultra-Fast-Track Cardiac Anesthesia in Coronary Artery Bypass Grafting Surgery

NCT07207421 | Completed

• 1 other identifier: ADYU-ANS-NY-012
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial aims to evaluate the impact of Ultra-Fast-Track (UFT) anesthesia on postoperative recovery in patients undergoing elective coronary artery bypass grafting (CABG). UFT anesthesia targets extubation in the operating room or within the first hour after surgery, whereas standard care involves transfer to the intensive care unit (ICU) with subsequent extubation according to routine protocols. A total of 100 patients will be randomized in a 1:1 ratio. The primary outcome is the maximum Vaso-Inotropic Score (VIS) within the first 24 postoperative hours. Secondary outcomes include postoperative pain scores (VAS), Quality of Recovery-15 (QoR-15) scores, opioid and analgesic requirements, ICU and hospital length of stay, time to mobilization, and postoperative complications. This study seeks to determine whether UFT anesthesia can safely reduce inotropic support requirements and enhance early recovery following CABG.

Conditions

Coronary Artery Disease; Coronary Artery Bypass Graft (CABG)

Keywords

Coronary Artery Bypass Graft (CABG); ultra- fast track anesthesia; Vaso-Inotropic Score (VIS); Postoperative recovery; Cardiac anesthesia

Outcome Measures

Primary Outcomes (1)

• Vaso-Inotropic Score (VIS)

  The Vaso-Inotropic Score (VIS) will be calculated hourly based on recorded inotrope and vasopressor infusion rates using the standard VIS calculation method. The primary outcome is the maximum (peak) VIS value observed during the first 24 postoperative hours. VIS values will be extracted from infusion charts and/or electronic medical records.

  From the end of surgery (0 hour) up to 24 hours postoperatively, with hourly assessments

Secondary Outcomes (2)

• Quality of Recovery (QoR-15) score

  24 hour postoperatively

• Postoperative pain score (VAS)

  Postoperative 2, 4, 6, 8, 12, and 24 hours (within the first 24 hours after surgery)

Study Arms (2)

Ultra-Fast-Track Anesthesia group

EXPERIMENTAL

Patients will receive standard general anesthesia for cardiac surgery. Extubation will be targeted in the operating room or within the first postoperative hour before ICU transfer.

Procedure: Ultra-Fast-Track Anesthesia

Standard care group

ACTIVE COMPARATOR

Patients will receive standard general anesthesia for cardiac surgery. They will remain intubated upon ICU admission and will be extubated according to routine ICU protocols.

Procedure: Standart care anesthesia

Interventions

Ultra-Fast-Track Anesthesia PROCEDURE

General anesthesia for cardiac surgery followed by planned extubation in the operating room or within the first postoperative hour before ICU transfer.

Ultra-Fast-Track Anesthesia group

Standart care anesthesia PROCEDURE

Extubation will be targeted in the ICU according to respiratory effort.

Standard care group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged ≥18 years undergoing elective coronary artery bypass grafting (CABG)
• Patients suitable for Ultra-Fast-Track anesthesia as determined by the anesthesia team
• Ability to provide written informed consent

You may not qualify if:

• Emergency CABG or combined cardiac procedures (e.g., valve surgery)
• Preoperative shock or requirement for mechanical ventilation
• Severe pulmonary disease (e.g., GOLD stage 3-4 COPD, home oxygen therapy)
• Severe hepatic failure or end-stage renal disease requiring dialysis
• Pregnancy
• Inability to provide informed consent or follow-up

Sponsors & Collaborators

• Adiyaman University Research Hospital: lead

Study Sites (1)

Adıyaman University Training and Research Hospital

Adıyaman, Adıyaman Province, 02200, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Model Details: This study is a prospective, randomized, controlled, parallel assignment trial with two groups. Participants undergoing elective coronary artery bypass grafting (CABG) will be randomized in a 1:1 ratio to either Ultra-Fast-Track anesthesia with early extubation (intervention group) or standard extubation in the intensive care unit (control group).

Study Record Dates

• First Submitted: September 19, 2025
• First Posted: October 6, 2025
• Study Start: October 1, 2025
• Primary Completion: December 15, 2025
• Study Completion: December 31, 2025
• Last Updated: February 10, 2026

Record last verified: 2026-02

Locations

TU (1)